STUDY ON ASPIRIN-MAA HYDROGEL MIP SYSTEM

LIU Xiaohang1,2 CHENG Guoxiang1 LI Guohua3 1. Scholl of Material Science and Engineering, Tianjin University, Tianjin 300072, China 2. Key Laboratory of Functional Polymer Material, Nankai University, Tianjin 300071, China 3. Scholl of Chemical Engineering, Hebei Industry University, Tianjin 300130, China  

The controlled release system of MIP-Asp hydrogel was prepared by using self-assembly molecular imprinted technique (MIP). 1H NMR was used to detect the changes of active hydrogen atoms. Moreover, the effect of crosslinking degree of hydrogel on the release of medicine was investigated and the temperature/pH sensitivity was also considered. The results demonstrated that: the MIPs-Asp was a procedure involving the participation of active hydrogen; the lower crosslinking degree corresponded to the higher medicine release ratio; high temperature is better for the release; weak acidity is better for the release of Asp.

【Key Words】： Aspirin 1H NMR MIPs.
【Fund】： Key Laboratory of Functional Polymer Material Nankai University
【CateGory Index】： Q503

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