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《Chinese Journal of Aesthetic Medicine》 2011-05
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Randomized,double-blind and own-controlled study on the effects of Centella triterpenes cream for melasma

HOU Wei,ZHANG Jie-chen,TIAN Wei-wei,Zhang Huai-liang,CHEN Jie-chun(Institute of Dermatology,Chinese Academy of Medical Sciences&Peking Union Medical College,Nanjing 210042,China)  
Objective To evaluate the efficacy of a Centella triterpenes creamR in treating women with melasma.Methods A double-blind,randomized,own-controlled 12 weeks split-face study was conducted.Centella triterpenes creamR was applied twice daily to half face and vehicle-control cream was applied to the other side.Efficacy was based on an investigator-blinded assessment,subject self-blinded assessment,and ChromameterRquantitative analysis at week 0,4,8 and 12.Results Thirty-six volunteer were recruited and all of them completed a 12-week trial.By the end of the study,MASI score decreased 45% on the treated side.Significant improvement was observed on treatment side,according to the Investigator's Global Assessment,volunteers self assessment,color measurement and photograph.Conclusion The study demonstrates that topical Centella triterpenes creamR is safe,tolerable,and clinically more efficacious than placebo in treating melasma.
【Fund】: 上海市科技创新行动计划2010年度中药现代化专项资助(项目编号:10DZ197030)
【CateGory Index】: R275
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【Citations】
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【Co-citations】
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1 Dai Yue~1 Cao Liang~(2,3) Chen Jie-Chun~4 Zhang Yah~4 Qian Li-Ya~(1,3) (1 China Pharmaceutical University Nanjing; 2 Nanjing University of Traditional Chinese Medicine Nanjing; 3 Jiangsu Provincial Centre for Chinese Medicine Quality Control Nanjing; 4 Shanghai Institute of Pharmaceutical Industry);Prophylactic Effects of Asiaticoside Ointment on Experimental Skin Pigmentation in Guinea Pigs[J];World Clinical Drugs;2007-08
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