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Randomized,double-blind and own-controlled study on the effects of Centella triterpenes cream for melasma

HOU Wei,ZHANG Jie-chen,TIAN Wei-wei,Zhang Huai-liang,CHEN Jie-chun(Institute of Dermatology,Chinese Academy of Medical Sciences&Peking Union Medical College,Nanjing 210042,China)  
Objective To evaluate the efficacy of a Centella triterpenes creamR in treating women with melasma.Methods A double-blind,randomized,own-controlled 12 weeks split-face study was conducted.Centella triterpenes creamR was applied twice daily to half face and vehicle-control cream was applied to the other side.Efficacy was based on an investigator-blinded assessment,subject self-blinded assessment,and ChromameterRquantitative analysis at week 0,4,8 and 12.Results Thirty-six volunteer were recruited and all of them completed a 12-week trial.By the end of the study,MASI score decreased 45% on the treated side.Significant improvement was observed on treatment side,according to the Investigator's Global Assessment,volunteers self assessment,color measurement and photograph.Conclusion The study demonstrates that topical Centella triterpenes creamR is safe,tolerable,and clinically more efficacious than placebo in treating melasma.
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