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Relationship between the change of distribution and proportion of type Ⅰ, Ⅲ collagen in human coronary arteries and coronary atherogenesis

Yang Fang;Zhao Peizhen;She Mingpeng,et al. (Cardiovascular institute and fuwai hospital,CAMS and PUMC,beijing, 100037)  
To investwite the chang on the expression of type Ⅰ、Ⅲ procollagen mRNA,the distribution of type Ⅰ、Ⅲ collagen fibers and the proportion of type Ⅰ and type Ⅲ collagen amount during formation and development of human coronary atherosclerosis(CAS). Methods The observation of the CAS types and of the change on distribution of type Ⅰ and Ⅲ collagen in the CAS plaques of specimens collected from the young and old subjects was performed using the stain of HE and picrosirius red;The analysis of expression of type Ⅰ、Ⅲ procollagen mRNA in normal coronary arteries and atherosclerotic plaques was done with the technique of hybridization in situ. Results (1)Along with the development of athrosclerotic lesion,type Ⅰ and type Ⅲ collagen deposition were increased simultaneously in coronay arteries; The expressions of type Ⅰ and type Ⅲ procollagen mRNA were up-regulated in plaques. (2)There were more cellular components and cells proliferation as well as predominant augmentation of type Ⅲ collagen fibers in the most plaques of the young subjects,and less numbers of cells and increased amount of type Ⅰ collagen fibers were obtained in most plaques of the aged people. Conclusions The over-expression of tyPe Ⅰ、Ⅲ procollagen mRNA was possibly related to the increase of type Ⅰ、Ⅲ collagen in atherosclerotic lesions; The proliferation of cell and augment of type Ⅰ、Ⅲ collagen and change of proportion of type Ⅰ and type Ⅲ collagen probably played an important role in the development of coronary atherosclerosis.
【Fund】: 国家“八五”科技攻关课题!85-15-03-04
【CateGory Index】: R363
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Chinese Journal Full-text Database 2 Hits
1 ZHENG Jianjie~1 MA Aiqun~2 WANG Hongyan~3GENG Xigang~1 LIU Jianlin~1 BAI Ling~2(~1Department of Cardiac Surgery, ~2Department of Cardiology, ~3Department of Pathology, the First Hospital of Xi′an Jiaotong University, Xi′an, 710061, China);Study on relationship between type Ⅰ collagen, NF-κB and atherosclerosis in human carotid artery[J];Journal of Clinical Cardiology;2006-07
2 Zheng Jianjie~1,Ma Aiqun~2,Wang Hongyan~3,Bai Xiaojun~2,Bai Ling~2(1.Department of Cardiosurgery;2.Department of Cardiology;3.Department of Pathology,First Hospital of Xi'an Jiaotong University,Xi'an 710061,China);Study on relationship between typeⅠcollagen,NF-κB and atherosclerosis in rabbits[J];Journal of Xi'an Jiaotong University(Medical Sciences);2005-05
Chinese Journal Full-text Database 1 Hits
1 Yang Fang; Zhao Pei-Zhen; Wang Ai-Zhong;et al.(Cardiovascular Institute and Fu Wai Hospital, CAMS and PUMC, Beijing 100037);Coronary Atheroscl erotic Lesions in Youth From Districts of High and Low Prevalences of Atherosclerosis[J];CHINESE CIRCULATION JOURNAL;1996-04
Chinese Journal Full-text Database 9 Hits
1 GAO Chun Fang 1, LI De Yan 1, WAN Wei Dong 2, WU Yan An 1, WANG Hao 1, KONG Xian Tao 1 (1.Department of Laboratory Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; 2.Department of Plastic Surgery) [;Analysis of sequence-specific DNA-binding protein of human α1(Ⅰ) procollagen gene with improved EMSA[J];Academic Journal of Second Military Medical University;2000-08
3 CHEN Zhong; ZHAO Pei-Zheng; WANG Ai-Zhong;HAN Xiao-Nan, YANG Fang and LIANG Feng-Ling (Department of pathology, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037. China);Comparative Study of Collagens in Coronary Artery Walls between Atherosclerosis Higher and Lower Prevalence Location[J];Chinese Journal of Arteriosc Lerosis;1995-01
4 Zhang Chun-Ling; Cong Xiang-Feng; Zhang Ying-Shan(Chang Ying-Shan)(Cardiovascular Institute,CAMS and PUMC,Beijing 100037)Deng Zhuo-Lin(Guangxi Medical College,Nanning 53007 );Effect of Human Aortic Heparan Sulfate Proteoglycan on the Growth of Cultured Human Aortic Smooth Muscle Cells[J];;1996-02
5 Wang Yanni,Zhao Yonghui,Zhu Jiaqing, et al. Department of Cardiology,the First Hospital of Xi'an Jiao Tong University, Xi'an (710061),Shaanxi;Effect of the Platelet Membrane Glycoprotein Ⅰa Gene Polymorphism in the Pathogenesis of Unstable Angina Pectoris[J];Chinese Circulation Journal;2002-02
6 Wang Jiang; Ni Can-rong(Department of Pathology,98th Hospital of PLA);Expression and significance of oncoprotein p53,rasp21 and p185 in carcinomas and polyps of the large intcstine[J];CHINESE JOURNAL OF PATHOLOGY;1994-02
7 Wei Lixin, Shi Huaiyin, Guo Aitao, et al. Department of Pathology, General Hospital of PLA,Beijing 100853;Morphologic discrepancies of coronary atherosclerotic lesions between patients with stable and unstable angina plus acute myocardial infarction[J];CHINESE JOURNAL OF PATHOLOGY;1998-03
8 Yang Fang *, Zhao Peizhen, She Mingpeng, et al. * Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037;The dynamic change of extracellular matrix in human coronary atherogenesis[J];CHINESE JOURNAL OF PATHOLOGY;1998-03
9 REN Bingwen, MA Ai-qun, LEI Xin-jun. Cardiology Dept, First Affiliated Hospital of Xi' an Jiaotong University, Xi'an 710061, China;The Effect of Type I Collagen and Its Degraded Fragment on Ox - LDL Uptaken by Monocytes[J];Journal of Chinese Microcirculation;2003-03
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 CHENG Zeng-lan, CHANG Qing.Department of Histology and Embryology, Medical College of Jinan University, Guangzhou,510632, China;The changes of collagen and MMP-2 in atherosclerotic rabbit aorta and effect of PACAP[J];Guangdong Medical Journal;2008-07
2 ZHU Ye-bin,WU Shuang,KONG Lin-lin;Formation of oxidized low density lipoprotein and the mechanism of atherosclerosis caused by Ox-LDL[J];Acta Academiae Medicinae CPAF;2009-01
3 Xue Hui,Guo Hua,Jiao Jieying(Department of Gastroenterology,The First Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710061,China);Protection of heme oxygenase-1 against hepatic ischemia reperfusion injury in cirrhotic rats[J];Journal of Xi'an Jiaotong University(Medical Sciences);2007-01
4 YUE Yan,HE Ping.(Department of Pediatrics,Second Affiliated Hospital of Kunming Medical College,Kunming 650031,China);Bilirubin and NF-κB[J];Medical Recapitulate;2009-03
5 ZHONG Hui-ju1,ZHANG Ying1,LI Qiang-xiang2,LI Guo1(1. Department of Endocrinology,Xiangya Hospital,Central South University,Changsha 410008;2. Institute of Political Science and Administration,Central South University,Changsha 410083,China);Effects of rAAV2/1-Acrp30 on NF-κB and adhesion molecule in GK rats with atherosclerosis[J];Journal of Xi'an Jiaotong University(Medical Sciences);2009-04
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