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Sereening of conditions of chemosensitivity of NSCLC with MTT colorimetric assay

Guo Yang;Wang Zenglin;Ren Jinrong,et al. (Department of cardiac-thoracic of affliated hospital of north china coal medical college,tangshan, 063000; Hebei cancer institute, shijiazhuang, 050011)  
To screen conditions of chemosensitivity of NSCLC. Methods Chemosensitivities of human NSCLC cells to various concentration gradients of nine antitumor drugs and their time-effect relationship were examined in vitro with MTT assay among 25 cases' fresh NSCLC tissues. Results Chemosensitivity of agents on NSCLC cells showed increasing gradually following the improvement of concentration of antitumor drugs and the extension of time and each kind of drug had it'S own trend. Conclusions The concentration of antitumor drugs of MTT assay should select the calculated in vivo drug concentrations and time should select 48 hours.
【CateGory Index】: R734.2
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