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《Chinese Journal of Ethnomedicine and Ethnopharmacy》 2009-08
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Effects of Dihydromyricetin on the content of ALT,AST,HA,LN,PC-Ⅲ,CⅣ in serums on hepatic fibrosis in rats

KUANG Manyuan,JIA Lei,LUO Mingying(Department of Anatomy Xiangnan Medical College,Chenzhou,423000,China)  
Objective:To observe the effects of dihydromyricetin on the content of ALT,AST,HA,LN,PC-Ⅲ,CⅣ in serums on hepatic fibrosis in rats induced by carbon tetrachloride(CCL4).Methods:Eighty four male SD rats were randomly divided into six groups:normal group,model group,Fufangbiejiaruanganpian group positive,lower,middle and high dosage of dihydromyricetin treatment groups.The hepatic fibrosis rat model was developed by subcutaneous injection of 40%CCL4 for 13 weeks.At the same time of modeling,rats were treated with dihydromyricetin at 25mg/100g,50mg/100g or 100mg/100g.Then the content of ALT,AST,HA,LN,PC-Ⅲ,CⅣ were detected in liver serums.Results:Compared with control group,the content of ALT,AST,HA,LN,PC-Ⅲ,CⅣ in serums of rats of model group all raised markedly(P0.01).Compared with model group,the content of ALT,AST,HA,LN,PC-Ⅲ,CⅣ in serums of rats of Fufangbiejiaruanganpian group positive and lower,middle and high dosage of Dihydromyricetin treatment groups reduced markedly(P0.05).Conclusion:Dihydromyricetin can protect hepatocytes from injury and prevent the progression of hepatic fibrosis in rats.
【CateGory Index】: R285.5
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