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《Chinese Journal of Ethnomedicine and Ethnopharmacy》 2009-08
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Esopiclone of Medicinal Chemistry

JIANG Wenjing(Shihezi medical schools,Shihezi,Xinjiang,832000)  
Insomnia drug therapy has a barbiturate,benzodiazepine class(BZ)and the three-stage non-BZ short-acting drugs.Zopiclone belongs to the nonbenzodiazepine class.Eszopiclone the(S)-enantiomer of the chiral hypnotic drug zopiclone,belongs to the cyclopyrrolone class of hypnotic drugs and acts as agonist at the type A γ-aminobutyric acid(GABA)receptor(ω1subtype)to improve the sleep quality.It has different characteristics in pharmacokinetics、pharmacodynamics and clinical treatment with benzodiazepine.This paper discusses the structure,physical and chemical properties、the discovery process,the structure-activity relationship,and pharmacological and pharmacokinetics characteristics of Eszopiclone.
【CateGory Index】: R914
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【References】
Chinese Journal Full-text Database 1 Hits
1 (Zhang Leiping1,Zhou Hong1,Zhang Yuzi2,Shu Cuixia2/1.Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China;2.Chinese People's Public Security University,Beijing 100038,China;3.China Medical University,Shenyang 110001,China);Deternination of eszopiclone in blood by liquid chromatography-tandem mass spectrometry[J];Chinese Journal of Forensic Medicine;2012-03
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Hong-yan,YUAN Yan-bo,HUANG Lan,LI Ling-zhi,SHU Liang(Institute of Mental Health, PekingUniversity,Beijing 100083,China);Safety and tolerance of (+)zopiclone after a single oral administration[J];The Chinese Journal of Clinical Pharmacology;2004-04
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Li Yong-zhen,Zhao Nan,Chi Mu-gen,Yang Ri-fang,Li Yun-feng,Zhang You-zhi,Yun Liu-hong(Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China);Synthesis and anxiolytic effects of 2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives[J];Journal of International Pharmaceutical Research;2010-04
2 HE Min1,JIN Ruo-min2,FU Sheng-guang2,JIANG Jian1(1.Shuguang hospital affiliated to Shanghai University of Traditional Chinese MedicineV; 2.Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China);Effects of Sanqifang on Expression of GABA_A mRNA in Hippocampus of Mouses[J];Liaoning Journal of Traditional Chinese Medicine;2011-09
3 YANG Xiao-long,HUO Xiao-ning.The Third People's Hospital of Lanzhou City,Lanzhou 730050,Gansu Province,China;The impact of the eszopiclone on daytime function in patients with depression accompanied by insomnia[J];Journal of Clinical Psychiatry;2012-06
4 YIN Han-dong,LI Gang,WANG Chuan-hua(Department of Chemistry,Liaocheng University,Liaocheng 252059,China);Synthesis and Crystal Structure of [Zn(O_2CC_6H_4NH_2-p)_2(1,10-phen)]·5H_2O[J];Journal of Instrumental Analysis;2006-05
China Proceedings of conference Full-text Database 1 Hits
1 Wenzhou Kanguing Hospital,Wenzhou 325007,China Chen Yuan-ling Ye Feng-zhen Tang Wei Tai Yon Liu Jia-hong;Comparison study of dexzopiclone in the treatment of insomnia[A];[C];2011
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Hong-yan,YUAN Yan-bo,HUANG Lan,LI Ling-zhi,SHU Liang(Institute of Mental Health, PekingUniversity,Beijing 100083,China);Safety and tolerance of (+)zopiclone after a single oral administration[J];The Chinese Journal of Clinical Pharmacology;2004-04
2 RUAN jing1, YAO Chen2,ZHANG Su-Min1, ZHANG Gao-Kui3(1.Hospital of Health Science Centre,Beijing University,Beijing 100083,China; 2.First Hospital of Peking University, Beijing 100034,China; 3.Chinese PLA General Hospital,Beijing 100853,China );Randomized controlled clinical trial on(+) zopiclone versus zopiclone in the treatment of insomnia[J];The Chinese Journal of Clinical Pharmacology;2006-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 GUO Jing-qi;SHI Yin-tao;WANG Hui-jun;Chongqing Institute of Forensic Science;;Qualitation and confirmation of zopiclone in blood by automated solid phase extraction and liquid chrommatography coupled to high resolution time-of-flight mass spectrometry[J];Chinese Journal of Analysis Laboratory;2014-09
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