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《Chinese Journal of Ethnomedicine and Ethnopharmacy》 2009-08
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Esopiclone of Medicinal Chemistry

JIANG Wenjing(Shihezi medical schools,Shihezi,Xinjiang,832000)  
Insomnia drug therapy has a barbiturate,benzodiazepine class(BZ)and the three-stage non-BZ short-acting drugs.Zopiclone belongs to the nonbenzodiazepine class.Eszopiclone the(S)-enantiomer of the chiral hypnotic drug zopiclone,belongs to the cyclopyrrolone class of hypnotic drugs and acts as agonist at the type A γ-aminobutyric acid(GABA)receptor(ω1subtype)to improve the sleep quality.It has different characteristics in pharmacokinetics、pharmacodynamics and clinical treatment with benzodiazepine.This paper discusses the structure,physical and chemical properties、the discovery process,the structure-activity relationship,and pharmacological and pharmacokinetics characteristics of Eszopiclone.
【CateGory Index】: R914
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Hong-yan,YUAN Yan-bo,HUANG Lan,LI Ling-zhi,SHU Liang(Institute of Mental Health, PekingUniversity,Beijing 100083,China);Safety and tolerance of (+)zopiclone after a single oral administration[J];The Chinese Journal of Clinical Pharmacology;2004-04
2 Zuo Daishu; Zhang Yafang; Shen Jianmin(Shenyang Pharmaceutical University,Shenyang 110015);Synthesis of a New Chemical Class of Sedative-hypnotic Zopiclone Analogues[J];CHINESE JOURNAL OF MEDICINEL CHEMISTRY;1996-01
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 LI Le-ping,DUAN Xue-min,CHEN Li-gong~* (College of Pharmaceuticals & Biotechnology,Tianjin University,Tianjin 300072,China);Synthesis of N-Alkyl-3-pyrrolidinones[J];Fine Chemicals;2005-02
2 YIN Han-dong,LI Gang,WANG Chuan-hua(Department of Chemistry,Liaocheng University,Liaocheng 252059,China);Synthesis and Crystal Structure of [Zn(O_2CC_6H_4NH_2-p)_2(1,10-phen)]·5H_2O[J];Journal of Instrumental Analysis;2006-05
3 Xu Jinghua(Department of Biochemistry, Shaoxing College of Art and Sciences, Shaoxing 312000)Gu Jianming(Central Laboratory, Hanzhou University, Hangzhou 310028);SYNTHESIS AND CRYSTAL STRUCTURE OF BIS(1,10PHENANTHROLINE) PHENYLACETATOZINC NITRATE[J];CHINESE JOURNAL OF INORGANIC CHEMISTRY;1998-02
4 LIU Qi , ZHANG Hong-yan ,RUAN Jin,LI Hua-fang, LI Jing, CHENG Yan, ZHANG Wei-wei ( Institute of Mental Health, Peking University, Beijing 100083, China; Hospital of Medical Center, Peking University, Beijing 100083, China; Shanghai Mental Health Center, Shanghai 200088, China; Huaxi Hospital Affiliated to Sichuan University, Chengdu 610041 , China; The General Hospital Affiliated to Tianjin Medical University, Tianjin 300052, China; The General Hospital of Beijing Military Area, Beijing ,100700, China);Efficacy and safety of eszopiclone in the treatment of insomnia[J];Chinese Journal of New Drugs;2006-08
5 XIAO Wei-dong1,ZHANG Hong-yan2,LI Ling-zhi2,SHA Sha2,SHU Liang2(1 Mental Health Center,People's Hospital of Wuhan University,Wuhan 430060,China;2 Institute of Mental Health,Peking University,Beijing 100083,China);The influence of eszopiclone treatment on blood pressure in healthy volunteers[J];Chinese Journal of New Drugs;2007-11
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Lianqi, LIU Xianchen, LIU Zhaoxi, et al Shandong Mental Health Center, Ji′nan 250014, China;Prevalence of sleep disorders in the urban elderly in Shandong province: a cross-sectional study[J];Chinese Journal of Psychiatry;2002-03
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