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《Chinese Journal of Ethnomedicine and Ethnopharmacy》 2009-08
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Esopiclone of Medicinal Chemistry

JIANG Wenjing(Shihezi medical schools,Shihezi,Xinjiang,832000)  
Insomnia drug therapy has a barbiturate,benzodiazepine class(BZ)and the three-stage non-BZ short-acting drugs.Zopiclone belongs to the nonbenzodiazepine class.Eszopiclone the(S)-enantiomer of the chiral hypnotic drug zopiclone,belongs to the cyclopyrrolone class of hypnotic drugs and acts as agonist at the type A γ-aminobutyric acid(GABA)receptor(ω1subtype)to improve the sleep quality.It has different characteristics in pharmacokinetics、pharmacodynamics and clinical treatment with benzodiazepine.This paper discusses the structure,physical and chemical properties、the discovery process,the structure-activity relationship,and pharmacological and pharmacokinetics characteristics of Eszopiclone.
【CateGory Index】: R914
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