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《Chinese Journal of Ethnomedicine and Ethnopharmacy》 2009-09
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Mycophenolate mofetil therapy versus cyclophosphamide treatment in patients with sever IgA nephropathy

Su Qinq Tao The pepole hospital of Luxi county 416000  
Objective: To compare the clinical efficacy of mycophenolate mofetil(MMF) with that of cyclophosphamide(CTX) in the treatment of sever IgA nephropathy.Methods:Forty-one patients with sever IgA nephropathy were enrolled into this study and were divided into MMF and CTX groups.MMF group included 15 cases that were treated with MMF at a dosage of 1.5 g/d.CTX group enrolled 14 cases that were given intravenous drip 0.4 g/2d and the total dosage was less than 8g.These patients were followed up for more than 12 months.The clinical efficacy and side effects were compared between the two groups.Results:①Clinical remission rate in the 12th month was 81% in MMF therapy and it was 57%in CTX group.The difference of the clinical remission rate between the two groups was significant(P0.05).②The concentration of proteinuria in 24h in MMF group was lower than that in CTX group(P0.05).③After the therapy,the level of blood-lipid decreased obviously in MMF group,but it did not changed in CTX group(P 0.05).④The side effect in both groups were 13%(MMF group) vs 43%(CTX group)(P0.05).Conclusion:The combination therapy of MMF and steroid was more effective than CTX intravenous drip in treatment of sever IgA nephropathy and with fewer side effects.
【CateGory Index】: R692.3
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【Citations】
Chinese Journal Full-text Database 3 Hits
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