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《Chinese Journal of Ethnomedicine and Ethnopharmacy》 2009-17
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The effect of Uygur Foeniculum vulgare Mill on collagen fiber of experimental hepatic fibrosis model in rats

Wu Xiao Cuan1,2,Wang Xin Xing1,Ma Xiu Min1,2,Zhu Min1,Hou Min1,Ma Jun3,Tian Su Ge1,Ding Jian Bing1,2 1.Xinjiang VIP Lab of great physician and pharmacology of traditional Chinese medical formulae,Urumqi,830011;2.Basic medical college in Xinjiang medical university;3.Traditional Chinese medical hospital in Xinjiang medical university 830000  
Objective:To study the effect of Uygur Foeniculum vulgare Mill on experimental hepatic fibrosis model in rats.Method: The model of hepatic fibrosis in rats was induced by CCL4.48 Wistar rats were divided into 4 groups randomly,ie,normal control group,model group,colhicines group,Uygur Foeniculum vulgare Mill preventive group.Live tissue of hepatic fibrosis was extirpated for pathologic examination with HE and Masson stains.Grade of hepatic fibrosis were evaluated.Hydroxyproline(HYP) was detected by the method of alkaline hydrolysis.Results: Staining of HE and Masson showed that degree of hepatic fibrosis in Foeniculum vulgare Mill preventive group was improved obviously(P0.05).Conclusions: Foeniculum vulgare Mil can be used to prevent rat hepatic fibrosis by reducing amount of collagen fiber and improve hepatic functions.
【Fund】: 新疆维吾尔自治区教育厅重点项目(XJED2008I17);; 新疆高技术研发项目(PT0708)
【CateGory Index】: R29
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