Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Universitatis Medicinalis Nanjing(Natural Science)》 2009-06
Add to Favorite Get Latest Update

Growth inhibition effect of triptolide on human endometrial cancer cells in vivo

ZHONG Jian,SUN Zhi-hua,WU Qiang,CAI Yu (Department of Gynecological Oncology, Jiangsu Cancer Hospital of NJMU, Nanjing 210009, China)  
Objective:To investigate effece of triptolide on the growth inbibitio of human endometrial cancer and to find out the role of triptolide on the expressions of Bcl-2 and VEGF. Methods:Human endometrial cancer cell line HEC-1B was seeded in the subcu- taneous and a implant xenograft model was established by using nude mice. Mice were randomly divided into five groups,then treated with 0.9% NaCl solution,high,middle,and low dose triptolide (8,4,2 μg / d each one) and DDP 40 μg / d each one for up to 10~15 days respectively. Tumor size was measured in 2 dimensions at regular time-intervals and the expressions of Bcl-2 and VEGF in tumor tissues were detected by SABC. Results:After treatment, the size of the xenografts in high-dose triptolide group were 894.802+ 81.519 mm3,compared with1771.702+114 mm3 in the control group (P 0.05,With inhibition rate of 50%). The expressions of Bcl-2 and VEGF in this group were significantly lower than that in the control group (P 0.05). Conclusion:High dose triptolide can sig- nificantly inhibit the growth of the xenografts of endometrial cancer HEC-1B in nude mice. The mechanism may be closely related to down-regulating the expressions of Bcl-2 and VEGF in tumor cells by triptolide.
【Fund】: 江苏省中医药局科技基金资助(HZ07029)
【CateGory Index】: R737.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 HUANG Xiao-hao,SUN Zhi-hua,WU Qiang(Department of Gynecological Oncology,Jiangsu Cancer Hospital Affiliated to NJMU,Nanjing 210009,China);The effect of triptolide on proliferation and apoptosis signal transduction pathway-PI3K/PKB in human endometrial carcinoma cell line[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2010-07
2 YIN Liang,WANG Liang,JIANG Wei-wei,KONG Lian-bao*(Department of Hepatic Surgery,the First Affiliated Hospital of NJMU,Nanjing 210029,China);The antitumor effect of triptolide on HepG2 cells in vitro and in vivo[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2011-02
3 ZHU Chuan-Shu;FENG Ming-Xing;MIAO Guo-Peng;FENG Jun-Tao;ZHANG Xing;Research & Development Center of Biorational Pesticide,Northwest Agriculture and Forestry University;Research Center of Biopesticide Technology and Engineering;;Effects of Ultraviolet-b(UV-B) Radiation and Ultrasonic Treatment on the Content of Three Secondary Metabolites in Tripterygium wilfordii Hook.f. Cell Suspension Cultures[J];Journal of Agricultural Biotechnology;2013-09
4 Huang Xiaohao;Zhou Xue;Department of Gynaecology,the First Affiliated Hospital of NJMU,Jiangsu Women and Children Health Hospital;Deparement of Gynaecology and Obstetrics,Nanjing Maternity and Child Health Care Hospital Affiliated to NJMU;;The effect of triptolide on the invasion in human endometrial carcinoma cell line(HEC-1B)[J];Journal of Nanjing Medical University(Natural Sciences);2013-10
5 LIU Xiao,WEN Rui-xing(College of Life Science and Biotechnology of Beijing University of Technology,Beijing 100124);The Research Progress on Antitumor Drugs with Traditional Chinese Medicine[J];Progress in Modern Biomedicine;2011-24
6 Wu Peiying(Xinzhou Occupation and Technology College,Shanxi 034000 China);Effect of Bcl-2 and Bax genes in treatment of endometrial cancer patients[J];Chinese Nursing Research;2010-36
7 DU Bingcheng1,QIAO Xiaoxia2,ZHANG Bin1,LEI Ming1,MA Yuanchun1,3 1College of Life Sciences,Northwest A&F University,Shaanxi Yangling 712100,China;2Ningxia Hospital of Traditional Chinese Medicine,Ningxia Yinchuan 750021,China;3Qinghai Health Colllege,Qinghai Xining 810000,China.;Effect of triptolide on PC-3 cell xenografts in nude mice[J];Journal of Modern Oncology;2012-12
8 LI Yana,b,YANG Yu-qi b,FENG Jun-taoa,WANG Yong-honga,ZHANG Xinga(aResearch and Development Center of Biorational Pesticide,Shaanxi Province Technology and Engineering Center of Biopesticide,b College of Life Science,Northwest A&F University,Yangling,Shaanxi 712100,China);Study on kinetic investigation of Tripterygium wilfordii adventitious root growth and nutrient consumption in vitro[J];Journal of Northwest A & F University(Natural Science Edition);2010-11
9 HUI Lu-Lu,XU Wen-Lin,CHEN Qiao-Yun,ZHU Xiao-Lan,LONG Lu-Lu,XU Ying,QING Rong Central Laboratory,Jiangsu University People Hospital,Zhenjiang 212002,Jiangsu Province,China;Effect of Triptolide on Sensitivity of K562/A02 Cell Line to Adriamycin[J];Journal of Experimental Hematology;2012-01
10 SUN Shi-bao,SHENG Yu-wen,YU Li-chun,QU Geng-qing,WANG Qing-jun(Dept. of Urology Surgery, The First Affiliated Hospital of Liaoning Medical College, Liaoning Jinzhou 121001, China);Effects of Mitomycin Combined with Celecoxib on the Proliferation of Bladder Cancer Cell Line T24[J];China Pharmacy;2013-17
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Li- hua, SUN Yong- chao, CHEN Ying (Pepartment of Pathology, Wuxi First Hospital of NJMU, Wuxi 214002, China);The relationship between CD44v6 and vascular endothelial growth factor expression in gastric carcinoma and its clinical signification[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2006-02
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 LI Yan-hua, BI Zhi-gang*(Department of Dermatology, the First Affiliated Hospital of NJMU, Nanjing 210029, China);The role of EGFR on UV-induced VEGF secretion of MEF[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2006-12
2 ZHANG Yu-hua, WU Wen-xi*, WEI Wei, WANG Guo-zhu (Department of General Surgery, the First Affiliated Hospital of NJMU, Nanjing 210029, China);Up-regualtion of vascular endothelial growth factor by hepatocyte growth factor in human colorectal carcinoma cells[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2007-03
3 LIU Wei,SHI Rui-hua,ZHU Hong,HAO Bo(Department of Gastroenterology,the First Hospital Affiliated of NJMU,Nanjing 210029,China);ITGA6、CTHRC1 expression in esophageal squamous cell cancer and their clinical significance[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2009-04
4 WU Qing-quan1,WU Jian2,CHEN Liang3 (1Department of Thoracic Surgery,2Department of Pathology,Huai'an First People's Hospital Affiliated to NJMU,Huan'an 223300;3Department of Thoracic Surgery,the First Affiliated Hospital of NJMU,Nanjing 210029,China);Expression and significance of MMP-2 protein in esophageal squamous cell carcinoma[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2012-09
5 YU Hong-chuan1,ZHANG Shu-qi2,ZHAO Li1(1.College of Life Science,Ningxia University,Yinchuan 750021,China;2.College of Agronomy,Ningxia University,Yinchuan 750021,China);Expression of vascular endothelial growth factor in the mice with digital lobule inflammation[J];Animal Husbandry & Veterinary Medicine;2009-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 MENG Ling-xin1, XUE Ying-jie2,ZHANG Ming-fang3, LI Qiang1,SONG Xi-yuan2, SUN Rui3, HAO Xi-shan1(1. Cancer Hospital of Tianjin,Tianjin 300060,China;2.Basic Department of Jining Medical College,Jining 272013,Shandong,China;3. Department of Pathology of Tianjin Medical University,Tianjin 300070, China);The Expression of bcl-2 and bax in Endometrioid Adenocarcinoma[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-03
2 YANG Jian-yi,GAO Bao-zhen,LI Li,WANG Wen-juan,GUO Hong-gang,BIAN Si-cheng(Department of Biology,Shanxi Medical University,Taiyuan 030001,China);Reproductive Cell Toxicity of Glycosides of Tripterygium Wilfordii Hook.f on Male Mice[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-05
3 SHAN Bao-en,YANG Jun-ling(Research Center of the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei,China);Mechanisms of Multidrug Resistance Reversal on B-MD-C1(ADR~(+/+))by Quercetin[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-05
4 Guo Juanjuan,Pan Xianglin,Feng Changwei,Zou Junhui (The Affiliated Hospital of Shandong Medical University,Jinan 250012,China);EFFECTS OF ORIDONIN ON INDUCING THE MULTI-DRUG RESISTANT CELL LINE K562/A02 TO APOPTOSIS AND REVERSING THEIR MULTI-DRUG RESISTANCE[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-03
5 ZENG Xiao Li1, TU Zhi Guang2 1.Clinical Laboratory of Anzhen Hospital,Capital University of Medical Sciences, Beijing,100029, P.R.China 2.Department of Clinical Biochemistry,Chongqing University of Medical Sciences, Chongqing,400016, P.R.China;Induction of Differentiation by Ginsenoside Rh_2 in Hepatocarcinoma Cell SMMC-7721[J];Chinese Journal of Cancer;2004-08
6 HUANG Yun-Hong1, ZHANG Sheng-Hua1, ZHEN Rui-Xian2, XU Xian-Dong1, ZHEN Yong-Su1 1.Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,100050, P.R.China 2.The First Peoples Hospital of Kaiping City, Kaiping,Guangdong,529300, P.R.China;Asiaticoside Inducing Apoptosis of Tumor Cells and Enhancing Anti-tumor Activity of Vincristine[J];Chinese Journal of Cancer;2004-12
7 DING Yi1, ZHANG Jie2, ZHAO Qing-Liang2, HOU Li-Jun2, WANG Qiu-Lin1, WANG Shu-Ren1 1. Department of Pathophysiology, Sichuan University, Chengdu, Sichuan, 610041, P.R. China 2. Department of Ophthalmology, Weifang Medical College, Weifang, Shandong, 261041, P.R. China;Effect of Triptolide on Expression of Urokinase-type Plasminogen Activators in Vascular Endothelial Cells[J];Chinese Journal of Cancer;2005-07
8 ZHANG Ni-Na1, BU Ping2, ZHU Hai-Hang1, SHEN Wei-Gan2 1. Department of Gastroenterology, Subei People's Hospital, Yangzhou, Jiangsu, 225001, P. R. China 2. Institute of Integrative Traditional Chinese and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, 225001, P. R. China;Inhibitory Effects of Scutellaria barbatae D. Don on Tumor Angiogenesis and Its Mechanism[J];Chinese Journal of Cancer;2005-12
9 ZHANG Jian, XU Zhuo-Qun, HU Qiang, QIU Xue-Wen, WANG Zhi-Rong Department of Urology, The First Affiliated Hospital in Wuxi City, Nanjing Medical University, Wuxi, Jiangsu, 214002, P. R. China;Effects of Selective Cyclooxygenase-2 Inhibitor on Proliferation and Apoptosis of Human Bladder Cancer Cell Line T24[J];Chinese Journal of Cancer;2007-04
10 Wu Ming Lang Jinghe Department of Obstetrics & Gynecology,Peking Union Medical College Hospital,CAMS & PUMC,Beijing 100730,China;Treatment of endometrial cancer[J];Oncology Progress;2006-01
China Proceedings of conference Full-text Database 1 Hits
1 CUI Lan1,2,QU Zhong-yuan1,2,ZOU Xiang1,2,HU Guo-jun1,2,JI Yu-bin1,2(1.Engineering Research Center of natural antineoplastic drugs,Ministry of Education,Harbin 150076,China;2.Center of Research and Development on Life Sciences and Environmental Sciences,Harbin University of Commerce,Harbin 150076,China);Study on the anti-tumor effects of Juglone in vivo[A];[C];2008
【Secondary References】
Chinese Journal Full-text Database 7 Hits
1 HAN Juan1,YANG Yan1,ZHU Chuan-shu1,2,WANG Yong-hong1,2*,ZHANG Xing1,2(1 Research & Development Center of Biorational Pesticides,Northwest A&F University,Yangling,Shaanxi 712100,China;2 Biopesticide Technology and Engineering Center,Yangling,Shaanxi 712100,China);Analysis of Differentially Expressed Genes in the Suspension Cell Culture of Tripterygium wilfordii Hook.f.with Elictor MeJA[J];Acta Botanica Boreali-Occidentalia Sinica;2012-12
2 LU Wei-hua CHEN Yong-fang WANG FangDAI Ning-bo HAO AI-hua LI Cui-fang JIA Su-er College of Agronomy,Xinjiang Agricultural University,Urumqi 830052,China;Effects of physical and chemical conditions on culture of Arnebia euchroma(Royle) Johnst hairy roots and content of shikonin and its derivatives[J];Journal of Huazhong Agricultural University;2012-01
3 HE Bei-hua(1.Sub-college of Medicine and Pharmaceutical Sciences of Hunan Environment-Biological Polytechnic College, Hengyang 421005,China;2.Life Science and Technology College of Nanhua University,Hengyang 421005,China);The Mechanism of Action and Material Basis of Immunopotentiator of Traditional Chinese Medicine[J];Journal of Hunan Environment-Biological Polytechnic;2012-02
4 Dong Jie Zhan Yaguang Ren Jian(College of Life Sciences,Northeast Forestry University Harbin 150040);Kinetics in Suspension Culture of Acer ginnala[J];Scientia Silvae Sinicae;2012-10
5 Wang Xiaofei,Wu qiang,Sun Zhihua,Li Haijin(Department of Gynecological Oncology,Jiangsu Cancer Hospital Affiliated to NJMU,Nanjing 210009,China);Triptolide induces caspase-dependent apoptosis in endometrial cancer via the mitochondrial pathway[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2013-02
6 Huang Xiaohao;Zhou Xue;Department of Gynaecology,the First Affiliated Hospital of NJMU,Jiangsu Women and Children Health Hospital;Deparement of Gynaecology and Obstetrics,Nanjing Maternity and Child Health Care Hospital Affiliated to NJMU;;The effect of triptolide on the invasion in human endometrial carcinoma cell line(HEC-1B)[J];Journal of Nanjing Medical University(Natural Sciences);2013-10
7 GAO Li,NIE Zhong-biao,CHAI Zhi,GUO Yu,WANG Yong-hui,YAN Run-hong,ZHOU Ran(Shanxi College of Traditional Chinese Medicine,Taiyuan 030024,China);Effects of Ethanol Extraction of Tripterygium wilfordiion Proliferation and Apoptosis in Bone Marrow Cells[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-19
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 YE Hui, WANG Wei,ZHANG Xing-lin,WU Shi-guo (Department of Surgery,Yuyao People’s Hospital,Yuyao 315400,China);The expression of CD44V6 in human gastric carcinoma[J];Anhui Medical and Pharmaceutical Journal;2005-07
2 CHEN Xiu-jiao~1,CHEN Jian-yang~2(1.Department of Pathology,Medicial College of Putian University,2.Department ofPathology,Affiliated Hospital of Putian University,Putian Fujian 351100,China);Relationship Between Expressions of CD44V6 and MMP-9 and Biology Behaviors in Gastric Cancer[J];Acta Academiae Medicinae Jiangxi;2005-05
3 Fan Kai-xi~1,Guo Qi-sen~1,Hu Wei~2(1.Department of Second Internal Medicine,Shandong Tumor Hospital,Jinan 250117,China;2.The First Affiliated Hospital of Jixing Medicial College,Nanchang 330006,China);Expression of CD44V6 and nm23-H1 in Gastric Cancer and Their Significance for Prognosis[J];Practical Clinical Medicine;2005-10
4 ZENG Wen-liang,FENG Mao-hui,HU Ming-bai,et al.(Department of Surgery,Hongan People's Hospital,Hongan 438400,China);Expression of VEGF and MMP-2 in gastric carcinoma and their roles in invasion and metastasis[J];Journal of Clinical Surgery;2005-10
5 Sha Yucheng, Yan Shijie;Clinical analysis of 70 patients with metastetic ovarian cancer[J];ACTA UNIVERSITIS MEDICINALIS NAHUI;1997-05
6 HU Mei-yi.Department of InternaI Medicine,Xian Fifth HospitaI,Xian 710082,China;The Clinical and pathological significance of expression of VEGF and CD34 in gastric carcinoma and MVD[J];Chinese Medicine of Factory and Mine;2005-02
7 SUN Yuan-shui,YE Zai-yuan,ZHAO Zhong-sheng,et al.(Zhejiang Provincial People's Hospital,Hangzhou 310014,China);The Expression of Vascular Endothelial Growth Factor-C in Gastric Cancer and Its Significance[J];Bulletin of Chinese Cancer;2005-02
8 SUN Yi, HE Hui, MA Qiang, WANG Xing-yang, YANG Lin, HE Da-lin.Institute of Urology, Department of Urology, First Hospital, Xi′an Jiaotong University, Xi′an 710061, China;Clinical evaluation of BTAstat,NMP22,HA,survivin,CD44v6,VEGF and VUC in bladder cancer diagnosis[J];National Medical Journal of China;2005-35
9 YANG Shu-cheng~1,XU Chuan-hai~2(1.Department of Surgery, 2.Department of pathology, Yancheng Cancer Hospital,Yancheng Jiangsu 224003, China);Expression of CD44V6 in Gastric Carcinoma and Is Significance[J];Journal of Zhenjiang Medical College;2005-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved