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《Acta Universitatis Medicinalis Nanjing(Natural Science)》 2012-06
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Clinical effects of oxiracetam for treatment of vascular cognitive impairment in varying degree

HAN Ying,LIU Qing-rui,LI Lai-you,SHI Xin,WANG Jiao-lan(Department of Neurology,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China)  
Objective:To investigate the effects of oxiracetam treatment for vascular cognitive impairment(VCI) in varying degrees.Methods:Sixty patients with VCI were selected.Among them,30 patients were with vascular cognitive impairment no dementia(VCIND)and 30 patients with vascular dementia(VD).All patients received conventional base treatment and the oxiracetam treatment.The event-related potentials P300(ERP-P300) and Montreal cognitive assessment(MoCA) of all patients were observed and compared before and after the treatment.Results:After the treatment,the scores of MoCA of all patients showed improvement(VCIND:t = 11.886,P 0.01;VD:t = 2.242,P 0.05).After the treatment,ERP-P300 of the VCIND group was improved significantly,the latency period of ERP-P300(P300-PL) was significantly shortened(t = 5.799,P 0.01) while the amplitude(P300Amp) was significantly increased(t = 17.603,P 0.01);but the ERP-P300 of the VD group had no obvious improvement(PL:t = 1.414,P 0.05;Amp:t = 1.069,P 0.05).There were significant differences in the scores of MoCA,the latency period and amplitude of ERP-P300 between VCIND group and VaD group(t = 2.135,4.402,7.682,P 0.05).Conclusion:Oxiracetam are beneficial in the treatment of VCI,especially effective to the patients with VCIND.
【Fund】: 河北省卫生厅医学科学研究重点课题(20100422)
【CateGory Index】: R749.1
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 SHI Xin,HAN Ying,LIU Qing-rui,LIU Ming-shun,LI Zhen,ZHOU Qing-ru Department of Neurology,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Comparison of Montreal Cognitive Assessment Scale and event-related potentials in vascular cognitive impairment[J];Clinical Focus;2011-12
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Jian1,CAI Zhi-you2,YAN Yong2,et al.(1.Department of Neurology,the First People's Hospital of Chongqing,Chongqing 400011,China;2.Department of Neurology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;3.Chongqing Third Social Welfare Institution,Chongqing 400028,China;4.Chongqing Second Social Welfare Institution,Chongqing 400023,China;5.Chongqing Western-suburb Hospital,Chongqing 400050,China);Clinical study of Livin,VEGF and MMP-9 in serum of vascular dementia patients[J];Chongqing Medicine;2009-11
2 Chen Lin1,Hu Jun1,Chen Kangning1,Zhou Zhenhua1,Zhang Jiuquan2,Zhang Bo1(1Department of Neurology,2Department of Radiology,Southwest Hospital,Third Military Medical University,Chongqing,400038,China);Influence of dolichoectatic internal carotid artery on cognitive function[J];Journal of Third Military Medical University;2011-10
3 Chen Min1,Luo Xin2,Zhang Yufang2,Wang Ting3,Li Changqing2(1.Department of Neurology;2.Department of Pharmacy,Chongqing Red Cross Hospital,Chongqing 400020,China; 3.Xiangbei Welman Pharmaceutical CO.Ltd.Changsha 410329,China);Efficacy of combiration therapy with Kingtag and Oxiracetam for the patients with vascular cognitive impairment[J];Chongqing Medicine;2012-22
4 LI Peiyuan,LIU Yunxia,ZHU Qixiu(Department of Electromyogram,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);DETECTION OF P300 AND ITS SIGNIFICANCE IN PATIENTS WITH NON-DEMENTIA VASCULAR COGNITIVE IMPAIRMENT[J];Acta Academiae Medicinae Qingdao Universitatis;2012-05
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6 LIN Chu-qing,WANG Wen-feng,LIU Man-fen(The Fourth People′s Hospital of Shantou City,Shantou 515021,CHINA);Investigation on Recognition Function State of Cerebral Stroke[J];Heilongjiang Medical Journal;2012-03
7 LIU Shuyun,ZHANG Ping,JIANG Fusheng,et al(Department of Neurology,Nanhua Affiliated Hospital,University of South China, Hengyang,Hunan 421001,China);Nimodipine Combined With Nicergoline Treatment Ischemic Stroke Patinents With Vascular Cognitive Impairment[J];Journal of Medical Science in Central South China;2012-02
8 ZENG Hong-mei,DENG Li-ying,WANG Wei-dong,TU Jiang-long(Department of Neurology,the Second Affiliated Hospital ofNanchang University,Nanchang 330006,China);A Comparative Study of the Clinical Features of Alzheimer's Disease and Vascular Dementia[J];Acta Academiae Medicinae Jiangxi;2009-12
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10 SHI Xin,HAN Ying,LIU Qing-rui,LIU Ming-shun,LI Zhen,ZHOU Qing-ru Department of Neurology,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Comparison of Montreal Cognitive Assessment Scale and event-related potentials in vascular cognitive impairment[J];Clinical Focus;2011-12
【Secondary Citations】
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1 YAO Jing, SUN Xue-li, LIU Tao-sheng, et al. Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China;Correlativity of P_(300) event-related potentials and neuropsychological tests[J];Chinese Journal of Psychiatry;2003-03
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