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《Ningxia Medical Journal》 2018-08
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Expression and clinical significance of N-cadherin and E-cadherin in ovarian serous tumor

DING Yonghui;WANG Qianqian;GUO Hua;SUN Chunli;LI Jiong;Department of gynecology,General Hospital of Ningxia Medical University;Affiliated Hospital of Heze Medical College;Ningxia Medical University;  
Objective To detect the expression of N-cadherin and E-cadherin in ovarian serous adenocarcinoma,and to explore its role in the occurrence and transfer process of ovarian Serous adenocarcinoma. Methods The expression of N-cadherin and E-cadher in 15 cases of ovarian serous cystadenoma,and 15 cases of borderline ovarian serous cystadenoma and 45 cases of ovarian serous adenocarcinoma(differentiation of low,medium and high differentiation all 15 cases,FIGO stage Ⅰ ~ Ⅳ,4 cases were stage Ⅰ,8 cases were stage Ⅱ,14 cases were stage Ⅲ,19 cases were stage Ⅳ) were examined by immunohistochemical staining(SP).Results The positive rate for N-cadherin expression in the ovarian serous cystadenoma group,the borderline ovarian serous cystadenoma group and the ovarian serous adenocarcinoma groups(differentiation of low,medium and high differentiation) was 62. 2%(80%,73. 3%,33. 3%),26. 7%,0% and there were significant different(P 0. 05); The positive expression rate of N-cadherin was higher in the lower level tissue differentiation,but had no obvious difference in different clinical stages(P 0. 05). The expression of E-cadherin in the borderline ovarian serous cystadenoma group were significantly higher than those in the borderline ovarian serous cystadenoma group and the ovarian serous adenocarcinoma groups and there were significant different(P 0. 05). Conclusion N-cadherin is high expression and E-cadherin is low expression in ovarian serous carcinoma. The N-cadherin and E-cadherin may be related to the breeding,infiltration and growth of the ovarian serous glands cancer cells.
【Fund】: 宁夏自然科学基金资助项目(NZ16134);; 宁夏留学人员科技活动项目择优资助项目(2016494)
【CateGory Index】: R737.31
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