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《Ningxia Medical Journal》 2018-08
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The significance and the expression of PTEN in endometriosis

CHEN Hua;HAN Cailing;BAI Zhimiao;LI Wangshu;LI Juan;HA Chunfang;Department of gynecology,General Hospital of Ningxia Medical University;Ningxia Medical University;The Openating Room,General Hospital of Ningxia Medical University;  
Objective To investigate the expression of tumor suppressor gene PTEN and its clinical significance in endometriosis patients. Methods The expression of PTEN protein and mRNA in eutopic endometriosis,ectopic endometrium and normal endometrium were detected by immunohistochemistry and semi-quantitative reverse transcription polymerase chain reaction respectively.Results The expression of PTEN protein in endometriosis eutopic,ectopic endometrial tissue was weaker than normal endometrial tissue,which the differences were statistically significant(P 0. 05); The expression of PTEN mRNA in endometriosis eutopic,ectopic endometrial tissue was weaker than normal endometrial tissue,which the differences were statistically significant(P 0. 05).Conclusion The expression of PTEN protein and mRNA are high in patients with endometriosis and it may be one of the mechanisms to induce the disease.
【Fund】: 国家自然科学基金项目(81660251);; 宁夏自然科学基金项目(NZ17146);; 宁夏医科大学校级课题(XY2017120)
【CateGory Index】: R711.71
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