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《Ningxia Medical Journal》 2018-08
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Changes and significance of serum and urine PLGF and sFlt-1 in preeclampsia pregnant women

FAN Yang;HAN Xuechuan;YAN Bingqing;LI Juan;Department of Gynecology and Obstetrics,Ningxia People's Hospital;  
Objective To investigate the levels of placenta growth factor and soluble endothelial growth factor-1 in serum and urinary for preeclampia and the predictive value in preeclampsia. Methods Serum and urinary levels of PLGF,sFlt-1 were measured by enzyme-linked immunoassay in 120 women(32 to 37 weeks). Results Comparing with control group,the serum levels of PLGF(20. 6 ± 17. 5 vs. 151. 4 ± 162. 3) and sFlt-1(930. 1 ± 783. 9 vs. 188. 2 ± 60. 5),sFlt-1/PLGF scale(46. 6 ± 38. 0 vs. 2. 1 ± 1. 1)in preeclampsia patients were significantly different(P 0. 05). Comparing with the control group,the urinary levels of PLGF(24. 6 ±10. 4 vs. 37. 2 ± 10. 0) and sFlt-1(241. 6 ± 16. 9 vs. 188. 2 ± 31. 6) in preeclampsia patients were significantly different(P 0. 05). Comparing with the control group,the urinary of sFlt-1/PLGF scale(23. 0 ± 38. 0 vs. 5. 8 ± 1. 8) in preeclampsia patients were no significantly different(P 0. 05). The serum levels of sFlts-1 were higher than in urinary(930. 1 ± 783. 9 vs. 241. 6 ±16. 9),the difference was significant(P 0. 05). Conclusion Compared with the control group,the levels of PLGF and sFlt-1,sFlt-1/PLGF in the serum are significantly different. The levels of PLGF and sFlt-1 in the urinary are significantly different. Maternal serum and urinary of PLGF and sFlt-1,sFlt-1/PLGF scale can be used as predictive marker of preeclampsia.
【Fund】: 宁夏自然科学基金资助项目(NZ17190)
【CateGory Index】: R714.244
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