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《Ningxia Medical Journal》 2018-08
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Analysis of effect of St.John wort extract combined with menopause hormone therapy in treatment of perimenopause depressive disorder

LIU Xuxia;MENG Huanran;MA Zhenhua;GAO Fenxia;WANG Jinfang;YANG Caihong;Ningxia Medical University;Cardio-Cerebrovascular Hospital of Ningxia Medical University;  
Objective To evaluate of the effect and incidence of medical adverse events on St.John wort extract combined with menopause hormone therapy(MHT) in perimenopause depressive disorder. Methods 120 patients were divided into four groups: 40 patients in group A(MHT),40 patients in group B(St.John wort extract combined MHT),40 patients in group C(St.John wort extract) and all patients had complete all clinical data. All patients had an evaluation of Hamilton depression scale(HAMD) with prior treatment,and an evaluation of effect on HAMD scores of decrease and incidence of medical adverse events. Results There were no difference between three groups in HAMD scores and age before the intervene(P 0. 05); At the 4 th,8 th,12 th in three groups HAMD scores was different comparing with themselves of previous HAMD scores as the course of treatment progress(P 0. 05); At the 12 th week of treatment,the effect of group A and group B was different(P 0. 05),the effect of group B and group C was different(P 0. 05),there are no difference between group A and group C(P 0. 05). The effect of group B in treatment of perimenopause depression was superior than that in group A and group C; At the 12 th week of treatment,there was no difference between three groups of incident of medical adverse events(P 0. 05). Conclusion The effects of St.John wort extract combined menopause hormone therapy group in perimenopause depression has advantage than menopause hormone therapy group and St.John wort extract group,and the effect is fast,stable and lasting,and the rate of adverse reaction has no increase and has better compliance. It has certain guiding significance for clinical application.
【CateGory Index】: R749.4
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