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《Pesticide Science and Administration》 2018-11
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Determination of Impurities in Batch Analysis of Pesticide Technical Grades

Cao Lidong;Li Fengmin;Huang Qiliang;Wu Jinlong;Zhang Hongjun;Institute of Plant Protection,Chienese Academy of Agricultural Sciences;Institute for the Control of Agrochemicals,Ministry of Agriculture and Rural Affairs of the People's Republic of China;  
The most challenging work for batch analysis of pesticide technical grade(TG) is the qualitative determination of impurities. Impurities are considered to be the "fingerprints"of pesticide TG and are the important parameters to deduce the synthetic route of pesticide TG. The sources of impurities mainly include starting materials,reaction intermediates,and by-products from side reactions. The side reactions are mainly degradation,isomerization,hydrolysis,oxidation,over substitution,and rearrangement reactions. The general idea for determination of impurities is to deduce the tentative chemical structure based on mass spectrum and synthetic route. Further confirmation of the structure of impurity is conducted through the chromatographic and mass comparison with authentic impurity standard which is obtained by custom synthesis(including preparation from preparative chromatography) or commercial available standard. The structure identification of impurity standard is generally performed by NMR,mass spectrum(including high-resolution mass),IR,and X-ray etc.
【CateGory Index】: TQ450.7
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