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《Journal of Clinical Electroneurophysiology》 2007-03
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Analysis of encephaloflugram technology in 47 patients with depression

XU Weichun,LI Yajuan,WANG Xinrui,et al The Mental Health Center of Xi’an,Xi’an(710061),China  
Objective: By encephaloflugram technology (ET) to observe the change of neurotransmitters in the brain and brain function before and after drug treatment in patients with depression. Methods: the change of neurotransmitters in the brain and brain function was examibed before and the 2nd, 4th,6th week after drug tretment through ET in 47 patients who accord with Dignostic Criteria for depression of CCMD-3 for 4 times. Results:①The neurotransmitters such as GABA ,Glu, 5-HT, AchR and INH in brain in the patients group were higher than that in the normal group. The other neurotransmitters such as EXC, Ach,NE and DA in the brain in the patient group were lower-which had no significance between the patient group and the normal group (P 0.05);②As compared with the normal group ,both GABA and Glu in the patient group decreased significantly after 6 weeks of treatment(P0.01);③Ach in the patient group increased significantly (P0.01);④NE and 5-HT in the patients group is decreased significantly from the 2nd week to 4th week to the 6th week(P0.05);⑤Both HAMD and SDS scores in the patient group decreased significantly after 6th week of treatment(P0.01). Conclusion: Depression may be correlated with the neurotransmitters such as GABA, Glu, 5-HT, Ach, NE, DA, IN,H and EXC in the brain and unbalanced brain function.
【CateGory Index】: R749.4
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