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《Journal of Dermatology and Venereology》 2006-01
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The immunohistochemistry study of skin squamous cell carcinoma and actinic keratoses

GE Xin-hong,WANG Qi,TU Ping,et al.(Department of Dermatology,First Affiliated Hospital,Ningxia Medical College,Ningxia China)  
To explore the relationship between squamous cell carcinoma and actinic keratoses.Methods Expression of desmoglein 1 and E-cadherin was determined in the patients with 22 squamous cell carcinoma(SCC)and 20 actinic keratoses(AK)by immunohistochemistry techniques Results In normal human skin,desmoglein 1 and E-cadherin was strongly expressed throughout the intercellular space of the epidermal cells,as well as the follicular epithelium and sweet glands.In actinic keratoses the expression of desmoglein 1 and E-cadherin reduced in tumor cells.markedly reduced or absent in SCC.Conclusions Treatment of actinic keratoses should be aggressive to stop the progression to squamous cell carcinoma.
【Fund】: 华邦皮肤科教育和研究基金
【CateGory Index】: R739.5
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Chinese Journal Full-text Database 3 Hits
1 Zhu Xiaohua,Xu Jinhua.Department of Dermatology,Huashan hospital,Fudan University,Shanghai,200040;Meta-analysis on the efficacy and safety of topical imiquimod in the treatment of patients with actinic keratosis[J];China Journal of Leprosy and Skin Diseases;2006-11
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