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《Journal of Dermatology and Venereology》 2006-01
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Study of serum level of Interleukin and tumor necrosis factor in Patients with Vitiligo

WANG Jing-xia.DUAN Ai-xian.ZHANG Da-jun (Affiliated Hospital of Ningxia Medical college,Yinchun china)  
Objectiv To detect the level of Interleukin-6(IL-6),Interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in sera of patients with vitiligo and analyse their relationship to disease activity and disease type.Methods The serum levels of IL-6,IL-8 and TNF-α were measured in 76 patients with vitiligo and 20 healthy volunteers with radioimmoassay.Results The serum levels of all the cytokines tested in the progressive stage were higher than those in normal controls.The levels of IL-8 and TNF-α tested in the progressive stage were higher than those in the stable stage.The serum levels of IL-8 tested only were significantly different from in limitative type and extentive type.Conclusion IL-6、IL-8 and TNF-α maybe involve in the autoimmune mechanism of vitiligo and relate to disease activity and disease type.
【CateGory Index】: R758.41
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