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《Journal of Dermatology and Venereology》 2006-01
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Study on Serum Levels of Six Kinds of Sex Hormones in the Follicular Phase of Menstrual Cycle in Woman with acne vulgaris

YU Zhong-jao,LU Jie,DUAN Xin-suo,et al (Department of Dermatology,Affiliated Hospital of Chengde Medical College,Chengde Hebei China)  
Objective To investigate the levels of serum sex hormones changes in female patients with acne vulgaris.Methods The serum levels of luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradion2(E_2),testosterone(T),progesterone(P)and prolactin(PRL) in the follicular phase of the menstatal cycle were measured wifh Electro-chemiluminescence immunoassay(ECLl) in 30 adolescent female patients with acne vulgaris and 20 late-onset female patients with acne vulgaris,15 cases healthy adolescent female subjects and l5 cases healthy post adolescent female subjects over the age of 25 years old were selected as controls.Results The serum levels of E_2 of the adolescent female patients with acne vulgaris were significantly lower than that of normal controls(P0.05),the serum FSH levels of the adolescent female patients with acne vulgaris were significantly higher than that of normal controls(p0.05).The ratio of T/E_2 was significantly higher in the adolescent female patients with acne vulgaris than that of the controls(P0.01).The serum T levels of the late-onset female patients with acne were significantly higher than that of the normal controls(P0.05).Conclusions The study indicates that the level of serum E_2 is declined in adolescent female patients with acne vulgaris.The level of serum T is increased in female patients with late-onset acne vulgaris.
【CateGory Index】: R758.73
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