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《Journal of Dermatology and Venereology》 2006-01
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Clinical research of desloradine in the traatment of chronic urticaria

LI Zhan-guo,CHEN Yan-hui,TIAN Chun (The First Affiated Hospital of Xinxiang Medical college,Henan China)  
Objective The Study was designed to compare the efficacy and safety of desloradine and cetirizine in the treatment of chronic urticaria.Methods A randomized,open-label parallel comparative clinical trial was conducted in 78 patients.They were divided into two groups,treated wiht daily desIoradine 5mg,cetirizine 10mg respectively,The therapeutic results were observed on 14th day and 28th day,The recurrent rates were also reoorded one week after discontinuation of treatment.Results There Was similar clinical efficacy among the two drugs.The efficient rates of desloradine and cetirizine were 68.89%,60.60%at l4th day and 91.11%,84,85% at 128 th day,respectively.But there was no significantly statistical difference among the two groups(P0.05).The recurrent rates of desloradine and cetirizine were 28.89% and 36.36%,respectively.No obvlous side-effects appeared during the entire triaI.Conciusions Desloradine and cetirizine have high clinical efficacy and safety in the treatment of Chronic urticaria.
【CateGory Index】: R758.24
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