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Therapeutic effect of Haishengsu Injection on late stage of malignant tumors

CHEN Shou-guo,LIU Xiu-rong,YANG Xiu,et al.The Haisheng Oncology Hospital of Qingdao,Qingdao266031,China  
Objective To evaluate the efficacy and safety of Haishengsu Injection on multiple kinds of advanced malignancies.MethodsHaishengsu Injection was administrated in 128 cases of malignant tumors,which were stage Ⅲ or Ⅳ confirmed by histopathology or cytopathology.There was 8ml Haishengsu Injection solved in 100ml of saline,and was intravenously dropped from day 1 to day 20,repeated 10 days later.The regimen was repeated every 30 days.The eficacy was evaluated after 2 cycles according to RECIST criteria,and quality of life(QOL) was evaluated according to Karnofsky scores.The safety was evaluated after 1 cycle according to NCI CTC3.0 version criteria.ResultsTotally 127 cases were evaluated for efficacy.And 295 cycles were completed and mean cycle was 2.3.Among 127 cases,there were 20 cases achieved PR,69 cases of SD,and 38 cases of PD.The objective response rate(RR) was 15.7%(20/127)and disease control rate(DCR)was 70.1%(89/127).The quality of life(QOL)were improved in 47 cases(37.0%),stabled in 54 cases(42.5%) and decreased in 26 cases(20.5%).There were 2 cases complicated measles and 3 cases had fever.ConclusionIt proved that Haishengsu Injection could improve the QOL of late stage of malignant tumor.It was worthy of clinical generalization and further application.
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