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《Chinese Journal of Clinical Rational Drug Use》 2010-01
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Stability study of cefamandole nafate for injection in four common transfusion solutions

LIU Min.The Children Hospital of Shenzhen,Guangdong,Shenzhen 518026,China  
Objective To study the stability of compatibility of cefamandole nafate for Injection in 5% glueose,10% glueose,5% glueose and sodium chloride,0.9% sodium chloride at 25℃.Methods The combination of cefamandole nafate and infusion fluids,the content of cefamandole nafate was determined by HPLC,and examine the appearance and changes of pH.Results No significant changes of appearance and content of the mixed solution of 5% glueose and sodium chloride,0.9% sodium chloride had been observed in eight hours.Conclusion Cefamandole nafate for injection when mixed with 5% glueose and sodium chloride or 0.9% sodium chloride is basically stable,while 5% glueose and 10% glueose shoud not be used.
【CateGory Index】: R942
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 CHEN Fang~* East Area,Municipal Hospital of Suzhou,Suzhou Jiangsu 215001,China;Stability Study of Cefpirome Sulfate for Injection in 4 Kinds of Different Infusions[J];Anti-Infection Pharmacy;2008-02
2 ZHU Shi-qing,NIU Chang-qun (R&D Drug Center,North China Pharmaceutical Corporation,Shijiazhuang 050015,China);LC-MS Analysis of Cefamandole Nafate[J];Journal of Instrumental Analysis;2007-S1
3 Liu Yu-fen (National Institute for the Control of Pharmaceutical and Biological Products, Beijing);SEPARATION AND QUANTITATIVE DETERMINATION OF CEFAMANDOLE NAFATE BY REVERSE PHASE HPLC[J];Chinese Journal of Antibiotics;1989-02
4 Fu Li-juan, Chen Rong(Wuhan Institute for Drug Control,Wuhan 430012);Feasibility Study of Determination of Sodium Carbonate by Titration in Cefamandole Nafate for Injection[J];Drug Standards of China;2008-04
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 WEI Shu-bo,SHI Ai-ming,ZHANG Quan-ying The No.2 Affiliated Hospital of Soochow University,Suzhou Jiangsu 215004,China;Stability of Cefoselis Sulfate for Injection Mixed with 4 Kinds of Transfusion[J];Anti-Infection Pharmacy;2009-02
2 ZHU Shi-qing,NIU Chang-qun (R&D Drug Center,North China Pharmaceutical Corporation,Shijiazhuang 050015,China);LC-MS Analysis of Cefamandole Nafate[J];Journal of Instrumental Analysis;2007-S1
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 WU Hua~(1),JIN Yong~(2),LIU Hua~(2) (1.Department of Pharmacy,First People's Hospital of Heifei,Hefei,Anhui 230061;2.Pharmacy School,Anhui Medical University,Hefei,Anhui 230032);On stability of the compatibility of five antibiotics with xylitol injection[J];Anhui Medical and Pharmaceutical Journal;2006-11
2 Liu Yu-fen (National Institute for the Control of Pharmaceutical and Biological Products, Beijing);SEPARATION AND QUANTITATIVE DETERMINATION OF CEFAMANDOLE NAFATE BY REVERSE PHASE HPLC[J];Chinese Journal of Antibiotics;1989-02
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