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《Chinese Journal of Clinical Rational Drug Use》 2017-02
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Determination of Voriconazole in the Human plasma by HPLC for Clinical application

CHEN Lu;TU Sui-ping;ZHANG Li-juan;Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital;  
Objective To establish the determination method of voriconazole the in Human Plasma by HPLC,and apply it to individualized treatment.Methods Blood samples were pretreated by using protein precipitation.Analytical column was Gemini C18(4.6 mm × 150 mm,5 μm),mobile phase was acetonitrile-glacial acetic acid(40∶60) at a flow rate of 1.0ml/min.Detection wavelength was set at 255 nm and temperature was kept at 35 ℃.Results Voriconazole showed good linear relationships in ranges of 0.227~ 13.540 μg/ml(r=0.999).Absolute recoveries of voriconazole were above 102.8%~113.6%,and relative recoveries were 106.3%~111.4%.Intra-day and inter-day RSD values were less than 5%.Conclusion The HPLC method is simple,quick and sensitive for drug monitoring on voriconazole.High concentration variability was observed among patients,and routine monitoring of voriconazole blood level may improve the drug safety.
【CateGory Index】: R96;O657.72
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【References】
Chinese Journal Full-text Database 1 Hits
1 Wang Lei;Liu Hongxing;Hebei Yanda Ludaopei Hospital;;Determination of concentration of voriconazole in patients with bone marrow transplantation by HPLC-MS/MS[J];中国实用医刊;2018-09
【Citations】
Chinese Journal Full-text Database 1 Hits
1 HE Gaoli;ZHANG Jing;Institute of Antibiotics,Huashan Hospital,Fudan University,Key Labaratory of Clinical Pharmacology of Antibiotics,Ministry of Health;;Voriconazole therapeutic drug monitoring:is it necessary?[J];中国感染与化疗杂志;2014-01
【Co-citations】
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1 ZHANG Jin;WEI Li;ZHANG Jian-jun;People's Hospital of Baoji;;Changes of Serum Levels of L- Homoarginine and Asymmetric Dimethylarginine and Their Correlations with Cardiovascular Disease in Patients with Type 1 Diabetes Mellitus[J];实用心脑肺血管病杂志;2015-09
2 Jiang Ling;Shan Qingwen;Wang Linlin;Tang Qing;Chen Xiuqi;Yang Shaoli;Zhang Zhi;Department of Pediatrics,the First Hospital Affiliated to Guangxi Medical College;;Effect of probiotics on intestinal flora and related cytokines in infants with cholestatic liver disease[J];中华实用儿科临床杂志;2015-12
3 DING Dao-xian;ZHU Xian-yong;ICU,the Second People's Hospital of Linhai;Clinical Laboratory,the Second People's Hospital of Linhai;;Protective effect of Live Combined Bifidobacterium and Lactobacillus Bacteria Tablets on intestinal mucosal barrier of patients with spontaneous peritonitis in cirrhosis[J];中国微生态学杂志;2014-05
4 HUA Chen;FU Tianxiao;FU Yongqing;ZHOU Jian;Department of Surgery,First Hospital Affiliated to Zhejiang Traditional Medical University;;Effect of Sijunzi Decoction Combined with Ischemia Preconditioning on Inflammatory Mediators and Ox-idative Stress in Rats with Hepatic Ischemia/Reperfusion Injury[J];浙江中西医结合杂志;2014-05
5 LIU Xiaoqin;Department of Infectious Diseases,the People's Hospital in Dianjiang;;Effect of Glutamine on the protection and immune function of intestinal mucosal barriers among patients with cirrhosis[J];胃肠病学和肝病学杂志;2014-04
6 Zhao Jianjun;Bi Xinyu;Huang Zhenl;Department of Abdomenal Surgery,Cancer Hospital of the Chinese Academy of Medical Sciences;;Effect of Different Nutrition Support Methods on Primary Liver Cancer Patients with Hepatectomy: a Controlled Prospective Study[J];医学研究杂志;2014-04
7 ZHANG Tianxiao;XIANG Yuanhua;Infectious Disease Department, Cangnan People's Hospital in Zhejiang Province;Department of Medicine, Luqiao Hospital of Taizhou People's Hospital in Zhejiang Province;;Influence and effect of bifid triple viable capsule on cellular immune function of patients with cirrhosis noninfectious diarrhea[J];中国现代医生;2014-10
8 LI Jun-hong;LUO Li-fei;Department of MedicineMSongyang People's Hospital;Clinical Laboratory,Taizhou Hospital;;The effect of bifidobacterium quadruple living bacterium on intestinal mucosal barrier and inflammatory factor of cirrhosis patients with spontaneous bacterial peritonitis[J];中国微生态学杂志;2013-12
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10 (LUO Wei-huan1,JIANG Chun-ping2,DING Yi-tao2 1.Nanjing University Medical College Nanjing,Jiangsu 210008,China;2.Department of Hepatobiliary Surgery,Affi liated Drum Tower Hospital of Nanjing University,Nanjing 210008,China);Construction and Identification of Eukaryotic Expression Vector pcDNA3.1(+)-ABCG2[J];肝胆外科杂志;2013-02
【Secondary Citations】
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1 WANG Li-jue1,2,TANG Hui-lin1, DUAN Jing-li1(1.Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China;2.Department of Pharmaceutical Administration and Clinical Pharmacy,School of Pharmaceutical Science,Peking University Health Science Center,Beijing 100191,China);Systematic review of influence on pharmacokinetics of voriconazole on CYP2C19 genetic polymorphisms[J];中国临床药理学杂志;2011-08
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