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《Chinese Journal of Clinical Rational Drug Use》 2017-02
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Determination of Voriconazole in the Human plasma by HPLC for Clinical application

CHEN Lu;TU Sui-ping;ZHANG Li-juan;Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital;  
Objective To establish the determination method of voriconazole the in Human Plasma by HPLC,and apply it to individualized treatment.Methods Blood samples were pretreated by using protein precipitation.Analytical column was Gemini C18(4.6 mm × 150 mm,5 μm),mobile phase was acetonitrile-glacial acetic acid(40∶60) at a flow rate of 1.0ml/min.Detection wavelength was set at 255 nm and temperature was kept at 35 ℃.Results Voriconazole showed good linear relationships in ranges of 0.227~ 13.540 μg/ml(r=0.999).Absolute recoveries of voriconazole were above 102.8%~113.6%,and relative recoveries were 106.3%~111.4%.Intra-day and inter-day RSD values were less than 5%.Conclusion The HPLC method is simple,quick and sensitive for drug monitoring on voriconazole.High concentration variability was observed among patients,and routine monitoring of voriconazole blood level may improve the drug safety.
【CateGory Index】: R96;O657.72
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1 Wang Lei;Liu Hongxing;Hebei Yanda Ludaopei Hospital;;Determination of concentration of voriconazole in patients with bone marrow transplantation by HPLC-MS/MS[J];中国实用医刊;2018-09
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9 ZHOU Jie;MENG Yong;DU Zhong-xiang;Laboratory of Functional Science,Xuzhou Medical College;;Effects of partial nutritional ingredient enriched in enteral nutrition on the liver function in cirrhotic rats[J];中国实用医药;2013-34
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【Secondary Citations】
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1 WANG Li-jue1,2,TANG Hui-lin1, DUAN Jing-li1(1.Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China;2.Department of Pharmaceutical Administration and Clinical Pharmacy,School of Pharmaceutical Science,Peking University Health Science Center,Beijing 100191,China);Systematic review of influence on pharmacokinetics of voriconazole on CYP2C19 genetic polymorphisms[J];中国临床药理学杂志;2011-08
2 ZHANG Ping-ping,WANG Ming-bo,ZHANG Jian1,LI Jun1(Wanjie Medical College of Shangdong,Zibo 255213;1.The center of Clinical Pharmacology,Shandong Provincial Hospital Affiliated to Shandong University,Ji′nan 250012);The gene polymorphism of CYP2C19 and drug interaction[J];齐鲁药事;2009-06
3 WU Xiao-jie,DONG Xiao-yi,CHEN Yi-jian,ZHANG Jing,SHI Yao-guo,WU Ju-fang,ZHANG Ying-yuan.(Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai 200040,China);A HPLC method for voriconazole therapeutic drug monitoring[J];中国感染与化疗杂志;2009-02
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