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《Chinese Journal of Clinical Rational Drug Use》 2017-06
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A comparative study on the efficacy of different administrations of meropenem in the treatment of severe pneumonia

WANG Yao;Leshan Specialized Seniors Hospital;  
Objective To investigate the clinical effect of different administrations of meropenem in the treatment of severe pneumonia. Methods A total of 96 cases of patients with severe pneumonia were selected from September 2013 to February 2016 in Leshan Specialized Seniors Hospital,which were randomly divided into A,B,C group,32 cases in each group.All groups were treated with meropenem,A group was continuous pumping,B group was prolonging the infusion,C group was given traditional intravenous infusion. The clinical effect,clinical indicator( T,WBC,Pa O_2,CPIS score,Pa O_2/ Fi O_2),results of drug susceptibility test in clinical isolates and length of ICU stay,absorption time of inflammatory exudation in lung,mechanical ventilation time and antibiotic expense were compared among the three groups. Results The clinical effect of A group was better than B,C group( P 0. 05). A group of T,CPIS score were lower than B,C group,WBC was less than B,C group,Pa O_2,Pa O_2/ Fi O_2 were higher than B,C group( P 0. 05). Sensitivity of isolated strain of A group was higher than B,C group( P 0. 05). The A group of length of ICU stay,absorption time of inflammatory exudation in lung,mechanical ventilation time were shorter than B,C group,antibiotic expense was less than B,C group( P 0. 05). Conclusion Continuous pumping meropenem is more effective than traditional intravenous infusion and prolonged infusion in treating severe pneumonia.
【CateGory Index】: R563.1
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