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《Chinese Journal of Clinical Rational Drug Use》 2017-06
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Clinical effect and safety of medopa combined with piribedil in the treatment of parkinson disease

LIU Hong;Department of West Pharmacy,Nanchong Central Hospital;  
Objective To discuss the clinical effect and safety of medopa combined with piribedil in the treatment of parkinson disease( PD). Methods A total of 47 PD patients were selected from June 2012 to December 2013 in Nanchong Central Hospital,which were divided into control group( n = 23) and combination group( n = 24). The control group was treated with medopa,combination group was treated with piribedil on the basis of control group,both groups were treated for 48 months. The clinical effect,UPDRS scores before treatment and after treatment of 12,24,36,48 months,and the incidence of adverse reactions were compared between the two groups. Results The clinical effect of combination group was better than control group( P 0. 05). Before treatment and after treatment of 12 months,no significant differences of UPDRS scores was found between the two groups( P 0. 05); after treatment of 24,36,48 months,the UPDRS scores of combination group were lower than control group( P 0. 05). There was no significant difference of adverse reactions rate between the two groups( P 0. 05). Conclusion Medopa combined with piribedil have an obviously clinical effect in the treatment of PD,it can lower UPDRS scores,improve the symptoms,and with good safety.
【CateGory Index】: R742.5
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