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《Chinese Journal of Clinical Rational Drug Use》 2017-07
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Prognostic analysis of 1072 patients with positive family history of coronary heart disease after PCI

GE Xin;ZHOU Yanmin;SUN Limin;Graduate School,Tianjin Medical University;  
Objective To analyze the prognosis of patients with positive coronary heart disease( CHD) family history( FH) after percutaneous coronary intervention( PCI). Methods 1072 patients with positive FH of CHD who underwent PCI in the hospital was selected as positive group,randomly selected 1000 patients with negative FH of CHD who underwent PCI from the same period as negative group. Baseline data include age,gender,body mass index( BMI) and coronary heart disease risk factors( smoking,diabetes,hypertension,hyperlipidemia). Mean follow-up time was 1 ~ 120( 59. 0 ± 23. 7) months,and the end point was cardiac death and death. The independent prognostic factors was assessed by Cox multivariate regression models,the survival rate was assessed by Kaplan-Meier survival curves. Results Patients in positive group and negative group had no difference in BMI and the incidence of diabetes,hypertension( P 0. 05); age of onset,smoking rate were significantly lower than that of the negative group( P 0. 05); the proportion of men and the incidence of hyperlipidemia were significantly greater than negative group( P 0. 05). Cox multivariate regression analysis: FH of CHD and application of statins were the protective factors of death in patients after PCI operation,and the age was the risk factor of that. FH of CHD and application of statins were the protective factors of cardiac death in patients after PCI operation. Kaplan-Meier survival curves analysis suggested that the survival rate and survival rate of cardiac death in patients with CHD were significantly higher than those in the negative group after PCI. Conclusion Positive FH of CHD is an independent protective factor for the prognosis of patients with PCI.The prognosis of the patients with positive FH of CHD who underwent PCI was better than negative ones.
【CateGory Index】: R541.4
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