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《Chinese Journal of Clinical Rational Drug Use》 2017-07
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Clinical effect observation of triple therapy in the treatment of diabetic nephropathy

JIANG Jianxiang;Department of Nephrology,The First People's Hospital of Xiangtan City,Hunan Province;  
Objective To observe the clinical curative effect of clopidogrel,irbesartan and slices of prepared astragalus combination in treatment of diabetic nephropathy. Methods 50 cases of diabetic nephropathy patients were randomly divided into treatment group and control group,with 25 cases of each group. Treatment group was given clopidogrel,irbesartan and astragalus slices triple therapy; control group was given irbesartan only,other treatments were same. The blood urea nitrogen( BUN),creatinine( SCr),and albumin( Alb) quantitation in 24 hours urine in two groups were detected before and after treatment. Results The assay indexes were improved after treatment in two groups. In treatment group 24 hours urine albumin quantitative,creatinine and urea nitrogen levels decrease significantly higher than that of control group,difference between the two groups was statistically significant( P 0. 05). After treatment,24 hours urine albumin quantitative of two groups were both improved than before treatment,SCr,BUN of the treatment group significantly improved compared with before treatment,24 hours urine albumin quantitative,SCr,BUN of treatment group decreased significantly higher than control group,the difference was statistically significant( P 0. 05). There was no significant difference in FBG between two groups before and after treatment( P 0. 05). During the treatment there were no adverse reactions due to the use of irbesartan,clopidogrel and radix astragali occurred. Conclusion Clopidogrel,irbesartan and astragalus slices the joint treatment of diabetic nephropathy is better than irbesartan only.
【CateGory Index】: R587.2;R692.9
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【Citations】
Chinese Journal Full-text Database 3 Hits
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【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 JIANG Jianxiang;Department of Nephrology,The First People's Hospital of Xiangtan City,Hunan Province;;Clinical effect observation of triple therapy in the treatment of diabetic nephropathy[J];临床合理用药杂志;2017-07
2 LIANG Qingqing;MENG Peijun;JIN Min;ZHANG Liping;HE Yanling;ZHANG Aihua;LI Shurong;GUO Xiaoguang;LIU Chao;School of Public Health ,Baotou Medical College;;Determination of trace lead in Astragalus membranaceus(Fisch.) Bge. var. mongho licus(Bge.)Hsiao by graphite furnace atomic absorption spectrometry[J];包头医学院学报;2016-11
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