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《Chinese Journal of Clinical Rational Drug Use》 2017-07
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Clinical effect observation of enalapril combined with hydrochlorothiazide in treatment of children with acute glomerulonephritis

LIU Fengjun;HAN Zhengli;LIU Lili;Department of Pediatric,Linzi District People's Hospital of Zibo City,Shandon Province;  
Objective To analyze the clinical efficacy and safety of enalapril combined with hydrochlorothiazide in treatment of children with acute glomerulonephritis,and provide a reference for the selection of treatment for children with acute glomerular nephritis. Methods 64 children with acute glomerulonephritis from January 2015 to February 2016 in hospital were randomly divided into observation group and control group,with 32 cases in each group. Two groups of children were full of rest,and control group were treated with captopril tablets combined with hydrochlorothiazide tablets treatment,observation group were treated with enalapril combined with hydrochlorothiazide treatment,two groups were in 10 days for a course of treatment,clinical symptom improvement time,clinical curative effect and drug adverse during the treatment were compared between two groups. Results Edema elimination time,the blood pressure returned to normal time,urine protein levels returned to normal time and gross hematuria disappeared time of observation group were all shorter than that of control group( P 0. 05). After one course treatment,the clinical total effective rate of observation group( 93. 75%) was higher than that of control group( 81. 25%)( P 0. 05). The adverse reaction rate of observation group( 3. 12%) was lower than that of control group( 15. 62%)( P 0. 05). Conclusion Enalapril combined with hydrochlorothiazide in treatment of children with acute glomerulonephritis,can significantly reduce the clinical symptoms improved time,improve the clinical efficacy,and is safe and reliable.
【CateGory Index】: R726.9
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