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《Chinese Journal of Clinical Rational Drug Use》 2017-11
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Discussion of methotrexate therapeatic window of malignate tumor and acute lymphoblastic leukemia

CHEN Lu;TU Sui-ping;ZHANG Li-juan;Department of Pharmacy,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital;  
Objective The clinical use of methotrexate in the treatment of maliganant tumor and acute lymphocytic leukemia,so monitoring the concentration of methotrexate and patients with elimination delay condition analysis and rescue.Methods EMIT was used to determine the concentrations of methotrexate in 24 h,48h,72 h.And the results were summarized and analyzed.Results EMIT was used to monitor the concentration of methotrexate in 342 case of 47 patients.Determination of the 20 patients,only 1 patient appeared in the determination of excretion delay.Monitoring the concentration of methotrexate in 342 cases of the 24 h,48 h,72 h were(48.13±31.75) μmol/L,(0.48±0.93) μmol/L,(0.08±0.07) μmol/L.Conclusions It is necessary to monitor the concentration of methotrexate when the patients μse methotrexate in clinic,in order to drug safety.Adverse reactions to patients with observation time,thus timely to rescue,to ensure the safety od drug.
【CateGory Index】: R969
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【Citations】
Chinese Journal Full-text Database 6 Hits
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【Co-citations】
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1 CHEN Lu;TU Sui-ping;ZHANG Li-juan;Department of Pharmacy,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital;;Discussion of methotrexate therapeatic window of malignate tumor and acute lymphoblastic leukemia[J];临床合理用药杂志;2017-11
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