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《Chinese Journal of Clinical Rational Drug Use》 2017-12
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Efficacy and safety Meta analysis of nifedipine in the adjunctive expulsive therapy of ureteral stones

ZHOU Meng-neng;LI Qing-yong;LUO Hong-li;Department of Pharmacy,the People's Hospital of Leshan;  
Objective To compare the efficacy and safety of nifedipine in the adjunctive expulsive therapy of patients with ureteral stones. Methods Databases including pubmed,embase,cochrane,CNKI,VIP,CBM,Wanfang were electronically searched for the randomized controlled trials on nifedipine in the adjnnctive expulsive therapy of patients with ureteral stones from inception to June 2016. Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed methodological quality. Then,Meta analysis was performed. Results A total of 11 studies involving 5468 cases of patients with ureteral stones were finally included. Compared with standard therapy or tamsulosin respectively,nifedipine showed higher or lower expulsion rate 〔RR = 1. 52,95% CI( 1. 10,2. 10),P = 0. 01; RR = 0. 83,95%CI( 0. 75,0. 92),P 0. 01〕,shorter or longer expulsion time 〔WMD =-2. 45,95% CI(-3. 41,-1. 48),P 0. 01;WMD = 2. 48,95% CI( 2. 40,2. 57),P 0. 01〕. The information was available for analgesic dosage in three trials( nifedipine vs standard therapy) or 7 trials( nifedipine vs tamsulosin). Nifedipine showed lower analgesic dosage than standard therapy in three trials( P 0. 05). Two trials showed that there was no significant difference between nifedipine and tamsulosin group( P 0. 05),while other five trials showed the opposite results( P 0. 05). Conclusion Nifedipine has a beneficial effect on the expulsion of ureteral stones,but the effective rate is lower than tamsulosin. Meanwhile,the rate of severe adverse reaction is similar between nifedipine and tamsulosin.
【CateGory Index】: R693.4
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