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《Chinese Journal of Clinical Rational Drug Use》 2017-14
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The clinical efficacy of imipenem/cilastatin with prolonged the infusion time on the treatment of severe pan-resistance Acinetobacter baumannii

GUO Yin;SU Jing-qiang;LUO Bang-jun;Guangzhou Fanyu District Central Hospital;  
Objective To observe and compare the clinical efficacy of tigecyclinc combined with imipenem/cilastation,imipenem/cilastation combined with cefoperazone sulbacta,prolonging intravenous infusion of imipenem/cilastatin combined with cefoperazone sulbactam on severe pan-resistance Acinetobacter baumannii. Methods 36 patients with severe pulmonary infection were randomly divided into trial group 1,2 and 3 with each group of 12 patients and ticyclinc combined with imipenem/cilastatin,imipenem/cilastatin combined with cefoperazone sulbactam,imipenem/cilastatin with prolonged intravenous infusion time combined with cephalosporins Paclitaxel were given each of these 3 groups respectively( P 0. 05). The clinical efficacy,bacteriological efficacy and laboratory data,changes of scoring system were compared. Results The clinical effective rate of group 3 were 66. 7%,higher than group 1 and group 2 with effective rate of 58. 3% and 50. 0% respectively.The total clearance rate of bacteria in group 3 was 58. 3%,which was higher than that in experimental group 1 and group 2 with41. 7% and 16. 7% respectively. The difference of effective rate between the two groups was significant( P 0. 05). The levels of temperature,WBC,N%,PCT APACHEⅡ of the three groups were significantly decreased compared to those before treatment,and the difference is statistically significant( all P 0. 05). Conclusion 3 hours of Imipenem/cilastatin infusion can improve the efficacy in treatment of severe pan-resistant patients with Acinetobacter baumannii infection,and it is suitable for applying to clinical treatment.
【Fund】: 广州市番禺区科技计划项目(No:2015-Z03-50)
【CateGory Index】: R516
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 Xu Kang;Shao Hua;Yu Feng;Zhan Ying;Department of Clinical Pharmacy, China Pharmaceutical University;Department of Pharmacy,Southeast University Affiliated Zhongda Hospital, Nanjing University;;Development of tigecycline for treatment of severe pneumonia infections due to multidrug-resistant bacteria[J];中国抗生素杂志;2016-08
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