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《Chinese Journal of Clinical Rational Drug Use》 2017-16
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The clinical effect observation of half dose intravenous gamma globulin and vincristine in severe new diagnosis of primary immune thrombocytopenia

SU Yonghong;Department of Hematology,The Shunyi District Hospital of Beijing;  
Objective To observe the clinical effect of half dose intravenous gamma globulin(IVIG) and vincristine(VCR) in severe new diagnosis of primary immune thrombocytopenia(ITP). Methods Selected 24 cases patients with ITP from September 2010 to September 2014,which was randomly divided into group A and group B,each group of 12 cases. Group A was treated by IVIG and VCR,group B was treated by IVIG. 2 groups were treated with conventional dose of glucocorticoid.After treatment,compared the clinical effect of 2 groups. Results The level of PLT in 2 groups before treatment was no statistic significantly(P 0. 05). The level of PLT on 3,7,14,28,90 days after treatment of 2 groups were higher than that before treatment(P 0. 05),but the difference between 2 groups after treatment was no statistic significantly(P 0. 05). Follow up for 2 years,the level of PLT in group A was higher than that in group B(P 0. 05). The total efficacy of 2 groups was no statistic significantly(P 0. 05).Follow up for 2 years,The basic cure rate of group A was higher than that of group B,the difference was statistically significant(P 0. 05). Conclusion Half dose intravenous gamma globulin(IVIG) and vincristine(VCR) in severe new diagnosis of primary immune thrombocytopenia(ITP) has an good effect,worthy of clinial application.
【CateGory Index】: R558.2
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Ouyang Wanyan;Yu Ziqian;Yin Jie;Zhao Xiaojuan;Wang Zhaoyue;Zhang Wei;Ma Zhenni;Su Jian;Bai Xia;Ruan Changgeng;Key Laboratory of Thrombosis and Hemostasis of Ministry of Health,Jiangsu Institute of Hematology,The First Affiliated Hospital of Soochow University,Collaborative Innovation Center of Hematology,Soochow University;;Acquired von Willebrand syndrome in three patients and literature review[J];中华血液学杂志;2016-08
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 SU Yonghong;Department of Hematology,The Shunyi District Hospital of Beijing;;The clinical effect observation of half dose intravenous gamma globulin and vincristine in severe new diagnosis of primary immune thrombocytopenia[J];临床合理用药杂志;2017-16
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