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《Chinese Journal of Clinical Rational Drug Use》 2017-16
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Expressions and significance of p57~(KIP2) in hydatidiform mole

HE Juan;SUN Qi;LU Meiying;Department of Pathological Section,The Fourth Affiliated Hospital of GuangXi Medical University;  
Objective To observe the expression of p57KIP2 protein in complete hydatidiform mole(CHM) and partial hydatidiform mole(PHM),and to explore the role and significance of p57KIP2 protein in the diagnosis and differential diagnosis of CHM and PHM. Methods Immunohistochemical method was used to detect the expression of p57KIP2 protein in 25 cases of CHM and 35 cases of PHM. At the same time,30 cases of placental tissue of edema abortion were selected as control group.Results The expression of p57KIP2 protein in chorionic villous cells and villus stromal cells of CHM was significantly lower than that of PHM and edematous abortion placenta,the difference was statistically significant(P 0. 05). Conclusion Immunohistochemical detection of p57KIP2 protein can be used as an important reference index in differential diagnosis of CHM and PHM.
【CateGory Index】: R737.33
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