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《Chinese Journal of Clinical Rational Drug Use》 2017-35
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Effect of rifapentine regimen on preventive treatment of tuberculosis

LI Xiao-fen;Sanming City Center for Disease Control and PreventionKnot;  
Objective To observe the preventive effect of tuberculin-positive patients,and to analyze the clinical value of different rifapentine-treated regimens for tuberculosis prophylaxis.Methods A total of 852 cases of tuberculosis positive cases were selected from the Centers for Disease Control and Prevention.According to the differences between the prevention and treatment programs,it was divided into the observation group and the control group with each group of 426 cases.The observation group received prophylactic treatment with rifapentine regimen.The control group was treated with isoniazid prophylaxis.The incidence of tuberculosis in 2 to 5 years were observed and compared.The occurrences of adverse reactions in the two groups after preventive treatment were analyzed.Results The incidence of 2-year tuberculosis in the observation group was2.82%(12/426),and the incidence of tuberculosis was 2.35%(10/426).The incidence of 2-year tuberculosis in the control group was 5.40%(23/426),and the incidence of tuberculosis was 3.05%(13/426).The incidence of adverse reactions in the observation group was 9.86%,which was lower than that of the control group 17.14%(P0.01).Conclusion Tuberculosis prophylaxis is the main means to reduce the incidence of tuberculosis patients with strong positive cases.Rifapentine as the current commonly used clinical drugs for curing tuberculosis has a significant effect on tuberculosis prophylactic treatment.The prevention effect is high and worthy of popularization and application.
【CateGory Index】: R52
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