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《Practical Journal of Medicine & Pharmacy》 2007-12
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Screening special biomarkers in serum of burn scar by using flight-mass spectrometry

ZUO Xin-cheng,ZHAO Guang,LI Dong-hui, et al. The Whole-army Institute of Military Training Medicine,the 150th Center Hospital of PLA, Luoyang 471031,China  
Objective At present mechanism of burn scar is not clear. This study aimed to establish a serum protein fingerprinting technique coupled with a pattern-matching algorithm to distinguish burn scar patients from common burn patients and healthy people. Methods Preliminary group and test group were both random selected serum samples.former group comprised 10 cases of common burn patient including 5 cases of Ⅰ degree burn and 5 cases of superficial Ⅱ degree burn; later group, 10 cases of burn scar patient including 5 cases of deep Ⅱ degree burn and 5 cases of superficial Ⅲ degree burn,35 cases of healthy people were selected as control. The sera of the test group was combined with the surface of the IMAC3 proteinchip. Then reading data of SELDI-TOF-MS was analyzed by Biomarker Wizard software and Biomarker Pattern software to get a classification rule of tree, which is standard configuration that can distinguish the sera of burn scar patients from the sera of healthy people and common burn patients, and the standard was approved test validity by double-blind method in the test group. Results At the key M/Z values of 5375,5717,4529,1225,1067,3883,66346Da protein contents of the three classes in preliminary group were obviously different each other by the software analysis(P0.05). And the classification rule of tree was discovered,and corresponding correct ratio was 100%(55/55),corresponding sensitivity was 100%(20/20) and corresponding specificity was 100%(35/35). After double-blind examining the test group with that rule, the corresponding correct ratio was 100%(55/55), the corresponding sensitivity was 100%(20/20) and the corresponding specificity was 100%(35/35).Conclusion Via comparative proteomics research in the sera of common burn patients, burn scar patients and healthy people, the group of protein is obviously different in burn pathological process.
【CateGory Index】: R644
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