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《Practical Journal of Medicine & Pharmacy》 2010-01
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miR-125b-1 gene mutation in lung cancer tissue and its relation with the clinico-pathological parameters and prognosis of patients

HUO Xüe-yun,SU Lin,ZHENG Yong-ming. Dept. of Respiratory Medicine,the Fourth People’s Hospital of Jinan City,Jinan,Shandong 250031,China  
Objective To investigate the role of miR-125b-1 gene in oncogenesis and progression of human lung cancer.Method PCR-SSCP was used to detect miR-125b-1 gene mutation in 119 specimen from primary site of lung cancer tissues and 42 samples of normal adjacent lung tissues.Result There were 40 cases of miR-125b -1 gene mutation ,and the analysis revealed that its mutation was positively correlated to the status of lymph node metastasis(P0.01) and clinical stage metastasis(P0.01),but no relationship was found between miR-125b-1 mutation and other clinical features.The postoperative survival time in patients with miR-125b-1 gene mutation was significantly longer than those with low expression (P0.05).Conclusion There is miR-125b-1 gene mutation in lung cancer tissue.miR-125b-1 gene mutation probably plays a crucial role in lung carcinogenesis.
【CateGory Index】: R734.2
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