Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Practical Journal of Medicine & Pharmacy》 2010-01
Add to Favorite Get Latest Update

Efficacy study on Risperidone alternated to Clozapine for Schizophrenia patients

SONG Ai-ping,WANG De-bao,GU Xue-fei,et al.The Second Veterans Hospital of Shan'xi Province,Huaying,SHan'xi 714200,China  
Objective To observe the efficacy of Risperidone alternated to Clozapine for Schizophrenia patients.Method The 120 schizophrenia patients who had been taken clozapine(300 to 100 mg/d)over 6 months were changed using clozapine tablet(named DANKE in Chinese)by oral within 1 month,and sustained 6 weeks.The effect was evaluated by the Positive And Negative Symptom Scale(PANSS),Clinical Global Impression Scale(CGI)score;the side effects were described and evaluated by Treatment Emergent Symptom Scale(TESS),extrapyramidal side effects scale(SAS)and descriptive record.Result After replaced by Risperidone for 6 weeks in poor efficacy Schizophrenia patients used clozapine,there were full recovery in 28 cases(23.33%),significant progress in 33 cases(27.50%),improvement in 24 cases(20.00%),non-response in 26(21.66%),and deterioration in 9 cases(7.50%).The clinical total effective rate was 70.83%.The incidence of clinical side effects was 56.66%,the majority of them was relatively minor,patients had a good tolerance.Conclusion After replaced by Risperidone for 6 weeks in poor efficacy Schizophrenia patients used clozapine,psychiatric symptoms are alleviated significantly,and adverse reaction is minor.These result should be as a reference to clinical applications.
【CateGory Index】: R749.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 Zhang Shoulai, Li Yeguang, Xu Janhua, et al. Rizhao Mental Health Center Shandong 276800, China;A double-blind study of domestic quetiapine and chlorpromazine in the treatment of schizophrenia[J];Shandong Archires of Psychiatry;2002-03
2 SUN Quan-xin,ZENG De-zhi,CHEN Ke-quan.The Second Affiliated Hospital of Xianning University,Xianning 437100,China;Clinical comparative study of ziprasidone in the treatment of schizophrenia.[J];Journal of Psychiatry;2007-03
3 LIU Guangjing,PAN Shili,WANG Xuegang,et al. The Forth People’s Hospital of Liaocheng City, Liaocheng 252000,China;A comparative study of olanzapine and risperidone in the treatment of schizophrenia[J];Journal of Psychiatry;2009-01
4 WEI Youfang,WANG Xiaofeng.Linyi Mental Health Center,Shandong 276005,China;A comparative study of ziprasidone and risper done in the treatment of schizophrenia[J];Sichuan Mental Health;2008-02
5 ZHANG Wen-he (Department of Psychiatry,Tzuchi General Hospital,Hualien TAIWAN 970,China);“Triple-five”principles of antipsychotic treatment[J];Chinese Journal of New Drugs and Clinical Remedies;2006-08
6 Xie Cong,Ni Xiao-Lin.The First Mental Diease Hopital of Chongiqng,Chongqing 400036,China;The Compared Study of Treating Schizophrenia with Risperidone Combining Clozapine[J];Journal of Preventive Medicine Information;2001-04
7 WU Bei lei (Wuhan Hanyang Rehabilitation Hospital, Wuhan 430050,China);Use of Anti psychotics among Chronic Schizophrenic Inpatients[J];Herald of Medicine;2001-07
8 MA Liwei,WU Haoran.Hebei VA Hospital.China.;A comparative analysis of drug treatment for inpatient of schizophrenia from front ten year to now.[J];Medical Journal of Chinese Civil Administration;2001-02
9 Ji Wei The Second People’s Hospital Shangqiu, Henan (Shangqiu 476000);The Effect of Quetiapine Chlorpromzine Clozapine on EEG[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2007-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved