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《Practical Journal of Medicine & Pharmacy》 2010-01
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Prevention & treatment efficacy of recombinant human growth hormone on obstructive jaundice of rat model

QI Qing-an,ZHU Jian-yong,WANG Jin-bo.Department of General Surgery,the 371st Hospital of PLA,Xingxiang,Henan 453000,China  
Objective To study the effect of recombinant human growth hormone(rhGH)on obstructive jaundice of rat model.Method One hundred and thirty six Spragure-Dawley rats were divided at random into three groups,namely group A(sham operation),group B(CBDL-BDR),and group C(CBDL-BDR-rhGH).Serum ALT,TBIL,TBA and TNF-α were detected.The postoperative change of liver by transmission electron microscope were observed.Result The accumulated mortality of rats in group C was 14.3%,much lower than that of 41.9% in group B(P0.05).Serum ALT,TBIL,TBA and TNF-α levels in group C were much lower than that in group B.The ultrastructure of hepatocyte observed by TEM showed that mitochondria swelling,bile canaliculi extending and microvilli reducing were relieved by rhGH.Conclusion The application of rhGH proved to be beneficial in enhancing surgical tolerance and safety,and in promotion recovery in obstructive jaundice rats.
【CateGory Index】: R657.43
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