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《Practical Journal of Medicine & Pharmacy》 2010-01
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Prevention & treatment efficacy of recombinant human growth hormone on obstructive jaundice of rat model

QI Qing-an,ZHU Jian-yong,WANG Jin-bo.Department of General Surgery,the 371st Hospital of PLA,Xingxiang,Henan 453000,China  
Objective To study the effect of recombinant human growth hormone(rhGH)on obstructive jaundice of rat model.Method One hundred and thirty six Spragure-Dawley rats were divided at random into three groups,namely group A(sham operation),group B(CBDL-BDR),and group C(CBDL-BDR-rhGH).Serum ALT,TBIL,TBA and TNF-α were detected.The postoperative change of liver by transmission electron microscope were observed.Result The accumulated mortality of rats in group C was 14.3%,much lower than that of 41.9% in group B(P0.05).Serum ALT,TBIL,TBA and TNF-α levels in group C were much lower than that in group B.The ultrastructure of hepatocyte observed by TEM showed that mitochondria swelling,bile canaliculi extending and microvilli reducing were relieved by rhGH.Conclusion The application of rhGH proved to be beneficial in enhancing surgical tolerance and safety,and in promotion recovery in obstructive jaundice rats.
【CateGory Index】: R657.43
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Chinese Journal Full-text Database 1 Hits
1 WANG Xiang-yu ZHENG Zhi-qiang LI Chun-ming LIN Sheng-zhang (Department of General Surgery, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325003);Effects of Recombination Growth Hormone and Somatostain in The Treatment of Serve Acute Pancreatitis[J];The Chinese Journal of Clinical Pharmacology;2003-02
Chinese Journal Full-text Database 10 Hits
1 CHEN Dong-li,DONG Guang-long,WANG Wei-zhong,LIU Ji,LI Ji-peng,LIU Xiao-nan (Department of Gastrointestinal Surgery,Xijing Hospital,the Fourth Military Medical University,Xi'an 710032,Shaanxi,China);Effcets of EN and growth hormone on the healing of fistula after total gastrectomy[J];Parenteral & Enteral Nutrition;2009-01
2 LIU Min,MA Dan,XIANG Jia-mei(Department of Nephrology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Restraining effects of human growth hormone and TPN on stress response after gastrointestinal carcinoma[J];Acta Academiae Medicinae Militaris Tertiae;2006-13
3 XU Mai-yu,ZHOU Meng-tao,SONG Hong-liang,et al.Department of Hepatobiliary Surgery,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000;Application of recombinant human growth hormone and enteral nutrition support after liver trauma operation[J];Journal of Hepatopancreatobiliary Surgery;2010-04
4 CAI Hui-hua, SUN Yue-ming, ZHAO Han-lin, MIAO Yi, SHI Yi (Department of General Surgery,the First Affiliated Hospital of NJMU,Nanjing 210029,China);The effect and possible mechanism of human recombinant growth hormone on proliferation of bile duct carcinoma and pancreatic carcinoma cell lines in vitro[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2007-05
5 CAI Hui-hua,SUN Yue-ming,SHI Yi,ZHAO Han-lin Department of General Surgery,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Province 210029,China;Influence of human recombinant growth hormone on proliferation of bile duct carcinoma cell line in vitro[J];Journal of Modern Oncology;2007-06
6 ZHANG Xiao-ping,HU Xin,LI Guangming,et al.Department of Oncology,Nanchong Central Hospital,Nanchong,637000;THE CLINICAL OBSERVATION OF REORGANIZED-HUMAN GROWTH HORMONE ASSOCIATE WITH TACE IN PRIMARY LIVER CANCER.[J];Modern Preventive Medicine;2006-08
7 ZHU Liang-hong,LI Juan1, ZHAO Guo-hai Department of Emergency Surgery, 1 Centre for Drug Clinical Evaluation, Wannan Medical College Yijishan Hospital, Wuhu 241001, Anhui, China;Meta-analysis on combination of growth hormone and somatostain and single somatostain in treatment of patients with severe acute pancreatitis[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2005-12
8 CHEN Xian-feng, LIU Zuo-jin, LI Xu-hong, YOU Hai-bo, GONG Jian-ping. Department of General Surgery, The 2nd Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China;Inhibition Effects of Recombination Human Growth Hormone and TPN on Stress Response of Postoperative Gastrointestinal Carcinoma Patients[J];Chinese Journal of Bases and Clinics in General Surgery;2006-01
9 YUAN Yuan,WANG Feng,ZHAO Xin,et al.;Meta Analysis of Recombinant Human Growth Hormone Interferes in Protein Catabolsm in Patients with Gastrointestinal Cancer Postoperation[J];Journal of Chinese Oncology;2011-06
10 WANG Jie-sheng,WANG Qin-xian,CHEN Fu-xin,LI Hong-chun,LUO Ke-xue Department of Cadre Health Care,Tongde Hospital of Zhejiang Province,Hangzhou 310012,Zhejiang,China;Somatostatin-induced hyperglycemia in case of diabetes and pharmacology analysis[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2011-11
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 WANG Xingpeng, WANG Bianxian, WU Jianxin, et al. Department of Gastroenterology, Shanghai First People's Hospital, Shanghai, 200080, China;Effect of growth hormone on pancreatitis-associated gut barrier dysfunction in rats[J];CHINESE JOURNAL OF DIGESTION;2000-01
2 WANG Fushun, ZHU Xi, LENG Xisheng. Department of General Surgery,Beijing University People′s Hospital,Beijing 100044,China;Postoperative changes of serum proteins and immune response in critical patients and the effects of recombinant human growth hormone[J];Chinese Journal of General Surgery;2001-06
3 Li Weiqin,Li Jieshou,Gu Jun,et al. Nanjing General Hospital of People′s Liberation Army,Nanjing 210002.;Molecular mechanism and therapy of hypoalbuminemia in peritoneal infection[J];Chiese Journal of Surgery;1997-02
4 Gu Jun,Li Jieshou,Li Weiqing,et al.Nanjing General Hospital of People′s Liberation Army,Nanjing 210002.;Influence of recombinant growth hormone on protein metabolism during severe infection:an animal experiment[J];Chiese Journal of Surgery;1997-02
5 Zhang Qunhua, Ni Qnanxing, Cai Duan, , et al. Department of Surgery, Shanghai Medical University, Shanghai 200040;Somastostatin and growth hormone in preventing liver damage due to acute necrotizing pancereatitis[J];NATIONAL MEDICAL JOURNAL OF CHINA;1998-08
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