Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Practical Journal of Medicine & Pharmacy》 2015-01
Add to Favorite Get Latest Update

Comparison on the acute toxicities of water soluble and non-water soluble chitosan in mice

LIN Ping;LIU Ying-hua;CHENG Yan-qin;Pharmacy Dept. of the PLA 401st Hospital;  
Objective To compare the toxic reaction of water soluble and non-water soluble chitosans in mice. Methods The maximum administration dosages of water soluble and non-water soluble chitosans were determined by administration in mice for two times continuously or by inject once a day. The acute toxic reaction was observed for consecutive 14 days. Results With the MTD of 4800 mg / kg,120 times as clinical dose,or with the maximum injection dose of 2400 mg / kg,all mice survived and there was no evident poisoning symptom in the observation period. And with ig or ip to mice,there was no difference in average weight among mice of chitosan groups and control group. Conclusion There is no acute toxicity from water soluble or non-water soluble chitosans at adult administration dosage.
【Fund】: 国家自然科学基金(编号:81102410)
【CateGory Index】: R994.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 LIU An-jun,ZHAN Wei,ZHU Zhen-yuan(College of Food Engineering and Biotechnology,Tianjin University of Science & Technology,Tianjin 300457,China);Study on Toxicology of Oligochitosan on Hair Removal in Mouse Model[J];Journal of Tianjin University of Science & Technology;2007-04
2 XU Wen-Hua;HAN Bao-Qin;KONG Xiao-Ying;LIU Wan-Shun;College of Marine Life Sciences,Ocean University of China;Medical College,Qingdao University;;Study on Anti-Tumor Effect of Chitooligosaccharides and Its Mechanism[J];Periodical of Ocean University of China;2013-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 NI Tian-qing,HU Si-yuan First Teaching Hospital of Tianjin University of TCM,Tianjin 300193,China;Research of pharmacologic action and clinical application of chitin and its derivative chitosan[J];Drugs & Clinic;2012-03
2 HU Xiao-liang,SHEN Jian(Fishery Machinery and Instrument Research Institute,Chinese Academy of Fishery Science;National R &D Branch Center For Aquatic Product Processing Equipment;Key Laboratory of Fishery Equipment and Engineering,Ministry of Agriculture;Shanghai,200092);Research Progress on Natural Antistaling Agent for Freshwater Fish[J];Modern Food Science and Technology;2013-04
3 QIAN Jun-qing;WU Hong-jun;College of Pharmaceutical Science, Zhejiang University of Technology;;Studies on Preparation and Antimicrobial Activity of Chitosan Particulates Prepared in Oil/Water Two-Phase System[J];Journal of Chemical Engineering of Chinese Universities;2014-05
4 WANG Lu-xia;WU Yan-li;MA Wen-ping;Heze Institute of Product Quality Supervision & Inspection;;The Preparation Method and Application Status of Chitooligosaccharide in Food[J];Journal of Anhui Agricultural Sciences;2014-32
5 Hu Xiao-liang,Zhou Guo-yan(Institute of Cryomedicine and Food Refrigeration,Shanghai University of Science and Technology,Shanghai 200093,China);Application of Chitosan and Its Derivatives on the Preservation of Fruits and Vegetables[J];Food and Fermentation Industries;2011-03
6 Hu Xiao-liang,Shen Jian(Key Laboratory of Fishery Equipment and Engineering,Ministry of Agriculture,Fishery Machinery and Instrument Research Institute, Chinese Academy of Fishery Science,National R &D Branch Center For Aquatic Product Processing Equipment,Shanghai 200092,China);Application of Chitosan and Its Derivatives on the Preservation of Aquatic Products[J];Food and Fermentation Industries;2012-08
7 XU Shi-zhao;SUN Jin;HE Zhong-gui;School of Pharmacy,Shenyang Pharmaceutical University;;Recent advance on materials of antitumor drug nanoparticles[J];Chinese Journal of Pharmaceutics(Online Edition);2007-03
8 WANG Zhi-hua;YAN Yong-bin;JIANG Yang-yang;LI Wei;QIN Cai-qin;Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables,Hubei Engineering University;Hubei Key Laboratory of Biomass-Resource Chemistry and Environmental Biotechnology,Hubei Engineering University;;Effect of Dietary Hydroxypropyl Chitosan on the Levels of Lead in Mice[J];Food Research and Development;2014-08
9 WANG Cheng;WANG Ling-wei;SHI Xiao-yu;YOU Mao-duan;XU Jian-yang;WANG-Lin;Department of Cardiothoracic Surgery, Affiliated Zhongshan Hospital of Dalian University;;Advances in Applications of Chitosan—Sodium Alginate Microsphere to Drug Carriers for Microparticulated Systems[J];Progress in Modern Biomedicine;2014-16
10 ZHAO Li-yan;ZHAO Zhong-peng;MA Shou-dong;CHENG Yan-qin;LI Ming-chun;Pharmacy of the,PLA Hospital;Academy of Military Medical Sciences;;Comparison analysis of antigrowth effects of four different chitosans on human colonic cancer LoVo cells[J];Journal of Tropical Medicine;2014-09
【Secondary Citations】
Chinese Journal Full-text Database 7 Hits
1 XU WEN-HUA,GE YIN-LIN(Department of Biochemistry and Molecular Biology,Qingdao University Medical College,Qingdao 266021,China);THE EFFECT OF siRNA ON THE EXPRESSION OF HUMAN GASTRIC CANCER CELL LINE SGC-7901[J];Acta Academiae Medicinae Qingdao Universitatis;2006-03
2 Huang Junming,Wu Liming,Chen ruiyi Health and Epidemic Prevention Station of Guangdong Province,Guangzhou 510300;Study on the Effects of Chitin and Chitosan on the Immune Function in Mice[J];GUANGDONG JOURNAL OF HEALTH AND EPIDEMIC PREVENTION;1999-01
3 XU Qing-song1,2,BAI Xue-fang1,DU Yu-guang1,(1.Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;2.Graduate School of Chinese Academy of Sciences,Beijing 100049,China);Progress on Anti-tumor Activity of Oligochitosan and Its Derivates[J];Food and Drug;2008-05
4 Wu Qingzhai, Qu Buhua, Li Deping, Dai Zurui, Zhang Shuying, Yuan Bojun The Pharmaceutical Research Institute of Jinling Hospital (Nanjing 210002);Toxicological Study of Chitin I . Studies on Acute Toxicity[J];Chinese Journal of Biochemical Pharmaceutics;1995-03
5 LI Yan-huan(College of LightIndustry and FoodSciences,South China University of Technology,Guangzhou 510640,Guangdong,China );BIOLOGICAL ACTIVITY OF CHITOSAN AND PROGRESSION ON APPLICATION IN HEALTH FOOD INDUSTRY[J];Food Research and Development;2009-04
6 YANG Jingzhi1, SUN Yanhua2, ZHANG Jiedao1, YANG Guodong1, TIAN Ming1(1. College of Life Sciences, Shandong Agricultural University, Taian 271018, China;2. College of Applied Chemistry and Material Science, Shandong Agricultural Univ ersity, Taian 271018, China);Study and Application of Developing Agent in Thin-Layer Chromatography for Ho ney Sugar[J];Chinese Journal of Chromatography;2003-04
7 TANG Yao1,ZHANG Shuangqing1,LI Xiang2,SUN Xu1,WEN Nie1, YU Min1,PENG Lili3,LI Jinrang3,LI Zuogang1*,LI Bo1(1.National Center for Safety Evaluation of Drugs,National Institutes for Food and Drug Control, Beijing 100176,China;2.College of Life Sciences,Jilin University,Changchun 130012,China; 3.Navy General Hospital,the Chinese People's Liberation Army,Beijing 100048,China);Determination of mitomycin C in rabbit plasma by ultra-high performance liquid chromatography-tandem mass spectrometry[J];Chinese Journal of Chromatography;2012-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved