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《Practical Journal of Medicine & Pharmacy》 2015-01
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Comparison on the acute toxicities of water soluble and non-water soluble chitosan in mice

LIN Ping;LIU Ying-hua;CHENG Yan-qin;Pharmacy Dept. of the PLA 401st Hospital;  
Objective To compare the toxic reaction of water soluble and non-water soluble chitosans in mice. Methods The maximum administration dosages of water soluble and non-water soluble chitosans were determined by administration in mice for two times continuously or by inject once a day. The acute toxic reaction was observed for consecutive 14 days. Results With the MTD of 4800 mg / kg,120 times as clinical dose,or with the maximum injection dose of 2400 mg / kg,all mice survived and there was no evident poisoning symptom in the observation period. And with ig or ip to mice,there was no difference in average weight among mice of chitosan groups and control group. Conclusion There is no acute toxicity from water soluble or non-water soluble chitosans at adult administration dosage.
【Fund】: 国家自然科学基金(编号:81102410)
【CateGory Index】: R994.3
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