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《Practical Journal of Medicine & Pharmacy》 2015-02
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Application of dezocine combined with sevoflurane anesthesia in the surgery for breast

ZHANG Zhong-li;WANG Ling;CHEN He-qin;The 150th Hospital of Chinese People's Liberation Army;  
Objective To observe the feasibility and effectiveness of postoperative analgesia of sevoflurane associated with dezocine for breast surgery,Methods ASAⅠ- Ⅱ120 female patients without underlying diseases were randomly divided into dezocine-sevoflurane group(group D),control group(C group),for each group n =60.Group D received such drugs according to dezocine 0.1mg / kg,sevoflurane concentration 7% to 8%,oxygen flow to4-5L / min,the lost consciousness patients were given muscle relaxants with insertion of the laryngeal mask for mechanical ventilation,kept the 1MAC of sevoflurane anesthesia;group C,conventional fentanyl 2-3μg / kg,propofol2 mg / kg,the lost consciousness patients were given muscle relaxants with insertion of the laryngeal mask for mechanical ventilation,intraoperative target propofol concentration 3μg / L maintained,Monitoring and recording at skin incision(T1),extubation(T2),4 hours after operation(T3),MAP,HR,Sp O2 changes and postoperative pain score,VAS Ramsay sedation score,the incidence of nausea and vomiting,recovery time were taken,Results In group D,MAP,HR at three time points were lower than in group C(P0.05);compared with the T1T3-SPO2 of C group was lower(P 0.05),Lower VAS score and,Ramsay score in D group than in group C after operation(P 0.05),no statistical difference between the two groups(P 0.05) in recovery time,Conclusion Dezocine combined with sevoflurane applied to breast surgery anesthesia with propofol and fentanyl is more stable and has better postoperative analgesic efficacy.
【Fund】: 洛阳市科技局攻关项目(1201052A-1)
【CateGory Index】: R614
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