Bone marrow-derived mesenchymal stem cells and their repair on spinal cord injury
CAO Juan;LI Xiu-yun;LI Chun-lan;Nurse Dept.of the General Hospital of Jinan Military Region;
Spinal cord injury(SCI) invariably results in the loss of neurons and axonal degeneration at the lesion site,leading to severe functional impairment,paraplegia,or tetraplegia. Currently,there is still no effective treatment for SCI. Long-term therapy after spinal cord injury focuses on rehabilitation,pain relief,spasticity treatment,and the prevention of complications. The ability of bone marrow-derived mesenchymal stem cell(BMSC) to self-renew and differentiate into multiple tissues,to modulate the immune system to prevent further neurodegeneration and effect repair outcome,or to provide a source of trophic support for the diseased nervous system,makes them an attractive candidate for clinical applications. This review highlights the biology and clinical applicability of BMSC for SCI.
【CateGory Index】： R651.2