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《Practical Journal of Medicine & Pharmacy》 2015-08
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Prevention & treatment and pathogenesis discussion of hypoproteinemia after acute cervical spinal cord injury

WANG Fei;YU Da-peng;ZHAO Ting-bao;Dept. for Repairing Spinal Cord,the General Hospital of Jinan Military Region;  
Objective To analyse hypoalbuminemia(Hypoproteinemia) mechanism following acute cervical spinal cord injury(acute cervical spinal cord injury,ACSCI),and to discuss its clinical features,as well as effective prevention and treatment methods. Methods The changes in the characteristics of 145 cases of spinal cord repair ACSCI patient's blood albumin from June 2012 to March 2014 in the General Hospital of Jinan military region.The older group included 65 patients grouped into(≥60 years old) the young group(60 years,80 cases);lung infection tracheotomy group(80 cases),no lung infection trachea uncut group(65 cases);110 cases were of completely injury group,35 patients incomplete injury;C2-C3 group of 20 cases,C4-C5 group of 85 cases;C6-C7 group of 40 cases who underwent the following tests:after admission were given with intravenous albumin and intestinal nutrition as early as possible and were encouraged self-feeding,blood was sampled every three days to be reexamination such as liver and kidney function indicators so as to analyze their serum albumin trends and to judge when to give the patient an intravenous infusion of albumin most effectively. SPSS15.0 software was applied for statistical analysis,t test was used in comparison inter- and intra- groups,P 0.05 when the difference was statistically significant. Results Differences of inter- groups was not statistically significant at admission(P0.05).In cervical spinal cord C4-C5 segments injury the incidence of low protein was significantly higher than other segments;in complete cervical spinal cord injury hypoproteinemia possibility was much higher than the incomplete cervical spinal cord injury. Lung infection inducing hypoalbuminemia was an important factor. 18 d,before admission,there were significant differences between both groups(P 0.05). Both's albumin index roughly was of the same trend. Conclusion Serum albumin after acute cervical spinal cord injury decreases rapidly,clinical treatment to correct it is of the difficulties;the impact of hormone therapy in the treatment of concurrent infections,and many other factors can all aggravate hypoalbuminemia;the patients with low protein induced by cervical spinal cord injury who can not eat immediately are given timely and adequately amounts of nutritional support as well as human serum albumin infusion which could effectively reduce the incidence of hypoal-buminemia;lung infections could aggravete hypoproteinemia.
【CateGory Index】: R651.2
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