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《Practical Journal of Medicine & Pharmacy》 2015-10
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Protective effects of somatostatin on liver injury in rats with traumatic brain injury complicated with hemorrhagic shock

WANG Li;WANG Hua-wei;LI Rui;Department of Special Examination,the 456th Hospital of Chinese PLA;  
Objective To investigate the effects of preconditioning with somatostatin(SST) on liver injury in rats with traumatic brain injury complicated with hemorrhagic shock(TBIS) and its underlying mechanisms.Methods The 36 male Wistar rats of clean grade were assigned randomly into 3 groups : sham operation group(C),TBIS model group and SST pretreatment group,each group included 12 rats. The arterial blood samples were taken for determination of serum levels of TNF-α,ALT and AST. The liver were removed for determination of levels of malondialdehyde(MDA),superoxide dismutase(SOD) and glutathione(GSH). Pathological changes in liver tissues were observed by light microscope. Results Compared with group C,the serum levels of TNF-α,ALT and AST and the liver levels of MDA were significantly higher(P 0.01),but the liver levels of SOD and GSH in group TBIS(P 0.01). The serum levels of TNF-α,ALT and AST and the liver levels of MDA were significantly lower(P0.01),but the levels of SOD and GSH in liver tissues were significantly higher(P0.01) in group SST than those in group TBIS. Histological examination revealed the injury of liver in TBIS group,and the rats in SST treated group showed alleviated severity of liver injury. Conclusion The supplementation of SST can ameliorate liver injury in rats with TBIS which may contribute to the inhibition of peroxide injury and oxygen free radicals.
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Xu Liyan;Liu Yao;Han Wenwen;Nan Chao;Li Dong;Hong Guangliang;Zhao Guangju;Lu Zhongqiu;Department of Emergency,the First Affiliated Hospital,Wenzhou Medical College;;Influences and mechanisms of somatostatin on inflammation in endotoxin-induced acute lung injury mice[J];中华危重病急救医学;2014-05
2 XU Hui-bin;WANG Qing;WANG Hua-fen;LIU Qi-feng;LIU Weng-qing;WANG Yong-qing;Department of Laboratory,88th Hospital of PLA;;Protective effects of ω-3 PUFA on the second liver injury in rats with traumatic brain injury and hemorrhagic shock[J];中华急诊医学杂志;2013-12
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 SONG Jing;ZHANG Yunping;Department of Senile Diseases,Friendship Hospital of Dalian City;;Effects of stem cell mobilization on TNF-α,IL-1β and pulmonary alveolar surfactant in rats with acute lung injury[J];河北医药;2017-09
2 ZHEN Jie;CHEN Wei;ZHU Xi;BIAN Wei-shuai;ZHAO Lei;SHENG Bo;Department of Intensive Care Unit,Beijing Shijitan Hospital,Capital Medical University;Department of Intensive Care Vnit,the Third Hospital of Peking University;;The protective effects of Methylprednisolone on rats with HCl-induced acute lung injury[J];河北医科大学学报;2016-06
3 Liu Jun;Wu Yunfu;Qiu Haibo;Department of Critical Care Medicine,Suzhou Hospital,Nanjing Medical University;Department of Critical Care Medicine,Nanjing Zhong-Da Hospital and School of Medicine,Southeast University;;Up-regulated expression of costimulatory molecule CD80 on dendritic cells in mice with acute lung injury[J];中华危重病急救医学;2016-06
4 WANG Li;WANG Hua-wei;LI Rui;Department of Special Examination,the 456th Hospital of Chinese PLA;;Protective effects of somatostatin on liver injury in rats with traumatic brain injury complicated with hemorrhagic shock[J];实用医药杂志;2015-10
5 Huang Xia;Cui Jiwen;Department Emergency Intensive Care Unit,Chongqing Three Gorges Central Hospital;;Effect of sustained inflation with different degrees of negative pressure for sputum aspiration in patients with acute respiratory distress syndrome on lung recruitment[J];中华危重病急救医学;2015-07
6 Tao Yifan;Tian Fangmin;Guo Xiangyang;Zhu Huaiqiu;Zhu Xi;Department of Anesthesiology,Peking University Third Hospital;;An evaluation of effects on induction of acute lung injury in mice by different doses of lipopolysaccharide and different durations[J];中国中西医结合急救杂志;2015-02
7 Zhong Mingmei;Zhang Lin;Wang Fan;Peng Song;Zhang Jin;Xuan Guoping;Department of Critical Care Medicine,Third Affiliated Hospital of Anhui Medical University;;The levels of angiopoietin-2 in patients with acute respiratory distress syndrome and its value on prognosis[J];中华危重病急救医学;2014-11
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Liu Huilin;Liu Guihua;Tian Zhaoxing;Department of Emergency,Peking University Third Hospital;;Changes in blood lymphocytes in sepsis patients[J];中华危重病急救医学;2014-03
2 WANG Qiao,ZHU Hong,ZHU Jian,ZHOU Long-nv Department of Emergency Medicine,the Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;Dynamic expression of Toll-like receptor 4 in septic acute lung injury in rats[J];中华实用诊断与治疗杂志;2011-02
3 SHAO Wei,FU Qiang,DU Chao(Department of Surgery Intensive Care Unit,Tianjin Nankai Hospital,Tianjin 300100,China);Influence of ω-3 PUFA on immunity of patients with severe intra-abdominal infection[J];肠外与肠内营养;2011-01
4 LUO Liang,LU Xiaoxian,ZHOU Shuqin(ICU,the Second Affiliated Hospital of Wuxi,Nanjing Medical University,Wuxi 214000,China);ω-3 PUFA Improves Immunologic Function of COPD Patients in IMV[J];临床医学工程;2010-12
5 LI Sha-luo,XU Yong-hua,WANG Xi,LIU Xue-feng,ZHAO Liang.Department of Emergency,Chinese Medicine Hospital of Jiading District,Shanghai 201800,China;Effects of enteral immunonutrition on immune function in patients with multiple trauma[J];中华急诊医学杂志;2010-11
6 LIU Yu,TANG Ji-chun,ZHANG Yan,ZENG Yin-ming.Department of Anesthesiology,The Fourth Affiliated Hospital, Suzhou University,Wuxi,Jiangsu 214062,China;Effects of hypertonic saline and pentoxifylline on pulmonary inflammation in rats with hemorrhagic shock[J];中华急诊医学杂志;2010-10
7 WEI Yu-zhe1,SONG Hong-jiang1,WANG Jia2,WANG Tie1,LAN Xiu-wen1,XUE Ying-wei1 (1.Department of Gastrointestinal Surgery;2.The Third Department of Gynecology,the Tumor Hospital of Harbin Medical University,Harbin 150081,Heilongjiang,China);The effect of omega-3 polyunsaturated fatty acids on elder patients after gastric cancer operation[J];肠外与肠内营养;2009-06
8 CHENG Xu-ping,ZHANG Yun-tao,FANG Qiang.SICU,the First Affiliated Hospital,Medial College of Zhejiang University,Hangzhou 310003,China;Comparison of the different ways of enteral nutrition in the patients with severe head injury[J];中国急救医学;2007-07
9 ZHANG Jinxiang WANG Hui XU Jianbo JIANG Chunfang WU Heshui. Department of Emergency Surgery,Union Hospital Affiliated to Huazhong University of Science and Technology,Wuhan 430022,China;Effects of Toll-like receptor 4 in lipopolysaccharide induced acute lung injury[J];中华急诊医学杂志;2006-08
10 MEI Xue,LI Chunsheng,WANG Shuo.Department of Emergency,Chaoyang Hospital,Capital(University) of Medical Science,Beijing 100020,China;Dynamic changes in serum levels of cytokines in patients with systemic inflammatory response syndrome[J];中国危重病急救医学;2006-02
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