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《Practical Journal of Medicine & Pharmacy》 2015-10
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Protective effects of somatostatin on liver injury in rats with traumatic brain injury complicated with hemorrhagic shock

WANG Li;WANG Hua-wei;LI Rui;Department of Special Examination,the 456th Hospital of Chinese PLA;  
Objective To investigate the effects of preconditioning with somatostatin(SST) on liver injury in rats with traumatic brain injury complicated with hemorrhagic shock(TBIS) and its underlying mechanisms.Methods The 36 male Wistar rats of clean grade were assigned randomly into 3 groups : sham operation group(C),TBIS model group and SST pretreatment group,each group included 12 rats. The arterial blood samples were taken for determination of serum levels of TNF-α,ALT and AST. The liver were removed for determination of levels of malondialdehyde(MDA),superoxide dismutase(SOD) and glutathione(GSH). Pathological changes in liver tissues were observed by light microscope. Results Compared with group C,the serum levels of TNF-α,ALT and AST and the liver levels of MDA were significantly higher(P 0.01),but the liver levels of SOD and GSH in group TBIS(P 0.01). The serum levels of TNF-α,ALT and AST and the liver levels of MDA were significantly lower(P0.01),but the levels of SOD and GSH in liver tissues were significantly higher(P0.01) in group SST than those in group TBIS. Histological examination revealed the injury of liver in TBIS group,and the rats in SST treated group showed alleviated severity of liver injury. Conclusion The supplementation of SST can ameliorate liver injury in rats with TBIS which may contribute to the inhibition of peroxide injury and oxygen free radicals.
【CateGory Index】: R285.5
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