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《Practical Journal of Medicine & Pharmacy》 2017-02
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Effects of two dialysis methods on parathyroid hormone and micro-inflammatory status in the patients with chronic renal failure:Comparative study

HUANG Bai-yong;LIN Xin-wei;Dept. of Nephrology,No.152 Hospital of PLA;  
Objective To investigate the effect of different dialysis methods on parathyroid hormone and micro-inflammatory state in patients with chronic renal failure. Methods A total of 136 patients with chronic renal failure who were admitted in author's hospital between February 2012 and March 2015 were selected as the study objects,and divided randomly into the observation group and the control group,68 cases in each. The observation group was treated with continuous ambulatory peritoneal dialysis(CAPD),while the control group was treated with hemodialysis(HD). The parathyroid hormone(PTH),C-reactive protein(CRP),serum amyloid protein(SAA),serum interleukin-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α) were compared between the two groups before and after treatment. Results After dialysis,the levels of serum PTH in the observation group [(37.89±9.61) pmol/L] was significantly lower than that before dialysis(P0.05). Compared with that in the control group after dialysis,there was no significant difference(P 0.05);After dialysis,the levels of CRP,SAA,IL-1β,IL-6 and TNF-α in observation group [(5.69±2.66) mg/L,(12.39±3.67) mg/L,(1.44±0.27) ng/L,(11.12 ±4.06) ng/L,(2.68 ±0.33) ng/L)] were significantly lower than those before dialysis and those in control group after dialysis(P0.05). Conclusion The effect of toxin removal of peritoneal dialysis and hemodialysis in patients with chronic renal failure is similar. Both of the two dialysis methods can effectively reduce parathyroid hormone level,but hemodialysis is more likely to cause chronic micro-inflammatory reactions.
【CateGory Index】: R692.5
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