Research progress on the something of F-box proteins family in tumor
PENG Kai-li;CHEN Hong-hui;Digestive Medicine Dept.,the Affiliated Hospital to University of South China;
F-box proteins regulate cell proliferation,apoptosis,metabolism,DNA damage repair,etc,mostly through decomposing ubiquitination of various target proteins,hardly any more they aren't involved in all life activities and regulate homeostasis.At present,a large number of studies help to define that F-box protein family is closely related to tumor cell metabolism and DNA damage. This paper reviews the relevant issnes such as the structural characteristics,functional classification and tumorigenesis of F-box proteins,thus providing rational bases for the design of F-box protien-targeted cancer terapies,as well diagnosis of cancer.
【CateGory Index】： R730.2