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Influence of enteral nutrition of liver cirrhosis patients on their liver function,serum protein levels,serum inflammatory factors and clinical effects

GUO Yan;Digestive Medicine Dept.,Xinxiang City's Central Hospital;  
Objective To explore the influence of enteral nutrition(EN) on their liver function,serum protein level,serum inflammatory factors and clinical efficacy in patients with liver cirrhosis. Methods The 172 cases with liver cirrhosis in author's hospital were selected in the study and were divided into control group and observation group(with 86 cases in each group) according to the random number table method. The two groups were given basic treatments of liver protection,removing jaundice,descending enzyme and inducing diuresis(with ascites),and control group was also given routine nutritional intervention,and observation group was also given EN intervention. The liver function indexes [total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST)],serum protein [serum tota protein(TP),albumin(ALB),transferrin(TF)],serum inflammatory factors [interleukin-21(IL-21),interleukin-10(IL-10)] and serum insulin-like growth factor-1(IGF-1) were compared between the two groups before intervention and 2 months after intervention,and the liver function grade(Child-Pugh grade) was recorded in the two groups 4 weeks after intervention. Results Two months after intervention,the levels of liver function indexes(TBIL,ALT,AST) and partial serum inflammatory factors(IL-21)in the two groups were lower than those before intervention(P0.05) while the levels of serum protein(TP,ALB,TF),partial serum inflammatory factors(IL-10) and serum IGF-1 were higher than those before intervention(P0.05),and the changes in observation group were greater than those in control group(P0.05). Two months after intervention,the severity of Child-Pugh grade was lower in observation group was lower than that in control group(P0.05). Conclusion EN has a protective effect on liver function damage in patients with liver cirrhosis,and has a good role in improving the nutritional status,and it also can alleviate the inflammatory response,thus favorable to outcome of patients.
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