Efficacy observation on intensity modulated radiation therapy and 3D conformal radiation therapy following surgery for breast cancer
XING Ai-min;ZHANG Nian-bo;LIU Ying-jie;Department of Tumor & Hematology,No.989 Central Hospital of PLA;
Objective To investigate the application efficacy of intensity modulated radiation therapy(IMRT) and three dimensional conformal radiation therapy(3 D-CRT) after surgery for breast cancer. Methods The 92 cases received breast-conserving surgery in 989 Central Hospital of PLA hospital from January 2015 to December 2017 were selected,and divided into control group and observation group,46 cases for each. Two groups were given breast-conserving surgery and chemotherapy. After chemotherapy of 2-3 courses,control group was given 3 D-CRT,while observation group was given IMRT. The exposure dose,matrix metalloproteinase-9(MMP-9),tissue inhibitor of metalloproteinase-1(TIMP-1) before and after chemotherapy,adverse reactions were compared between the two groups. Results All the 92 patients were finished radiotherapy,the exposure dose of the left side of lesions and affected side of lungs in observation group was significantly lower than that in control group(P0.05),the V105%,V110%,V115% of PTV in observation group were also did so(P0.05);The CI of observation group was significantly higher than that of control group,while the HI of observation group was lower than that of control group(P0.05);After radiotherapy,the MMP-9 levels of two groups decreased compared with those before radiotherapy(P0.05);There was no statistical difference in the TIMP-1 levels between the two groups before and after radiotherapy(P 0.05);The incidence of adverse reactions such as skin reaction,bone marrow suppression,radiation-induced lung injury,retrosternal pain,digestive disorder in observation group was lower than that in control group(P0.05). Conclusion Compared with 3 D-CRT,IMRT has better uniformity and conformity of PVT dose,and the exposure dose of endangered organs is low,which is beneficial to decrease the incidence of adverse reactions in the patients with breast cancer undergoing surgery.