Docetaxel or oxaliplatin combined with fluorouracil regimen in postoperative chemotherapy for gastric cancer:An analysis on the prognosis of patients
DANG Hai-zhen;JIAO Shun-chang;JIANG Zhong-hua;PLA No.971 Hospital;
Objective To compare the two chemotherapy schemes [docetaxel(DTX) or oxaliplatin(OXA combined with fluorouracil(5-FU)] in the postoperative treatment of gastric cancer(GC) patients,and analyse patient's prognosis. Methods From Jan. 2010 to Jun. 2011 42 cases were diagnosed as stage Ⅰ-Ⅲ GC and divided into two groups randomly:docetaxel(observation) group(21 cases),accepting docetaxel combined with 5-FU regimen,oxaliplatin(control) group(21 cases),accepting oxaliplatin combined with 5-FU regimen;Disease free survival(DFS) and untoward reaction were compared between the two groups. Results DFS of observation group was obviously higher than that of control group(P0.05);DFS was relevant to chemotherapy periodicity,operation incisal edge,chemotherapy toxin subsidiary reaction in observation group,compared with control group. Conclusion For postoperative gastric cancer patients undergoing chemotherapy,docetaxel combined with 5-FU can achieve good clinical effect,DFS is of obvious prolongation.