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《Journal of Qufu Normal University(Natural Science)》 2010-04
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Effects of Zhijujieyu-tang on Ability of Spatial Learning-memory and Expression of c-fos in Brain of Depression Model Mice

WANG Yu-qi,ZHANG Ya-nan,CHEN Ya-jing,LI Ya(College of Life Sciences,Qufu Normal University,273165,Qufu,Shandong,PRC)  
In this paper,we study the effects of Zhijujieyu-tang on the ability of spatial learning-memory and the expression of c-fos in chronic stress induced-depression model mice brain.Kunming mice were randomly divided into six groups:the normal control group,the model group,the positive control (fluoxetine) group,the high,medium and low concentration groups of Zhijujieyu-tang.The behaviors and the ability of spatial learning-memory of mice were determined by open-field test and Morris Water Maze,and the expression of c-fos in the brain were detected by immunohistochemical method.The results showed that the spontaneous activities and exploratory behaviors were remarkably decreased in the model group mice (P0.01),and the spatial learning and memory in them were significantly decreased (P0.05).The c-fos expression in the CA1,CA3,DG regions of hippocampus (HP) and prefrontal cortex (PFC) were significantly reduced in the model group mice (P0.05).Zhijujieyu-tang medium and high dosage groups can improve the behavior,the learning and memory function,and the expression of c-fos in HP and PFC.The results indicate that Zhijujieyu-tang possesses a certain antidepressant-like property and its mechanism may be closely related to the up-regulation of c-fos expression in HP and PFC.
【Fund】: 山东省自然科学基金(ZR2009DL009);; 曲阜师范大学“十一五”省级重点学科建设项目
【CateGory Index】: R285.5
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【Citations】
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【Co-citations】
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