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《Chinese Journal of Cancer Prevention and Treatment》 2012-01
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Prevention effect of mustard seed on colorectal cancer in rats induced by DMH in vivo

ZHU Ming-gu1,GUO Wen1,YUAN Hai-feng2,LI Xin-yan1,CHEN Chu-di1 1.Department of Gastroenterology,Guangdong Provincial Key Laboratory of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,P.R.China 2.Department of Gastroenterology,Heze Municipal Hospital,Heze 274614,P.R.China  
OBJECTIVE: To observe the effect of mustard seed(MS) against colorectal cancer in rats induced by 1,2-dimethylhydrazine(DMH) in vivo.METHODS: The colorectal cancer model induced by DMH intraperitoneal injection.The effect of mustard seed on the incidence of colorectal cancer,spleen index and thymus index were observed.RESULTS:The colorectal cancer model was successfully established in this experiment.The incidence of colorectal adenocarcinoma in DMH group was 83.33%(10/12),the adenoma incidence was 16.67%(2/12),the total tumor incidence was 100%(12/12),and the liver and mesenteric lymph node metastasis rate was 58.33%(7/12).The incidence of adenocarcinoma in 5% MS group and 7.5%MS group was 58.33% and 75.00% respectively lower than that in DMH group(χ2=15.662,P=0.000).The liver and mesenteric lymph node metastasis rate of colorectal cancer in 5% MS group and 7.5%MS group was 41.66% and 50.00% respectively lower than that in DMH group(χ2=8.585,P=0.014).And the incidence of total colorectal tumor in 5% MS group and 7.5%MS group was 66.67%(8/12) and 41.70%(5/12) respectively lower than that in DMH group(χ2=9.687,P=0.008).While the incidence of colorectal adenoma in 5% MS group(41.67%,5/12) and 7.5%MS group(33.33%,4/12) was slightly higher than that in DMH group(16.67%,2/12).The thymus and spleen index of rats in 7.5%MS group were markedly higher than that in DMH group(P=0.013;P=0.037).And the thymus index of rats in 5%MS group was also markedly higher than that of DMH group(P=0.039).CONCLUSION: MS have the effects of preventing colorectal cancer induced by DMH,and it can improve organism's immunefunction.
【Fund】: 广东省自然科学基金(9151040701000025);; 广东省科技计划项目(2010B060900054);; 南方医院院长基金(2009B011)
【CateGory Index】: R735.34
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 WU Zi-gang1,JIA Wen-ting2,CHEN Dong-yan1,YANG Li-li1,HE Min1,ZOU Bing1,WANG Jun-yi2,GAO Jin2 1.Department of Gastroenterology,Shenzhen Hospital of Peking University,Shenzhen 518036,P.R.China2.Molecular Biology Center,Institute of Biophysics Chinese Academy of Sciences,Beijing 010010,P.R.China;Relationship between expression of c-met oncogene and neoplasia of colorectal adenoma[J];Chinese Journal of Cancer Prevention and Treatment;2008-23
2 YUAN Hai-feng,GUO Wen,ZHU Ming-gu,CHEN Chu-di (Guangdong Provincial Key Laboratory of Gastroenterology,Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong 510515,China);The effect of mustard seed on azoxymethane-induced colorectal tumor in mice[J];China Oncology;2010-03
3 TAN Zhi-jie,LIANG Jun-ying,CUI Jian.Department of Medicine,The People's Hospital of Central District of Jinan,Jinan 250002,China;Preventive effects of Zafirlukast on colorectal cancer induced by azoxymethane in rats[J];Chinese Journal of Clinical Research;2010-10
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 He Wenfei,He Dawei,Ma Chao,Zhao Dan,Zhang Yongbo,Bian Zedong(Department of Urology,Children’s Hospital, Key Laboratory of Developmental Diseases in Childhood Cofounded by Chongqing Medical University and Ministly of Educaion,Chongqing Medical University,Chongqing,400014,China);Gallic acid inhibits growth of human neuroblastoma xenograft in mice[J];Acta Academiae Medicinae Militaris Tertiae;2011-02
2 WEN Chunmiao1,YANG Runping1,HU Jian1,JIAO Zelong2,YANG Yuguang1,YANG Jianling3,LI Hengjin1,ZHAO Hua1 1Department of Dermatology,General Hospital of PLA,Beijing 100853,China;2Department of Dermatology,Clinic Affiliated to Navy Headquarter,Beijing 100039,China;3Department of Dermatology,513 Hospital of PLA,Lanzhou 732750,China;Effects of mustard seed on 2,4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice[J];Journal of Southern Medical University;2012-04
3 WANG Liping1,2),ZENG Xianxu3),NIU Fenglan4),SHI Zhuo2) 1)Department of Histology and Embryology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001 2)Department of Pharmacology,College of Basic Medical Sciences,Jilin University,Changchun 130021 3)Department of Pathology,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 4)Department of Hygienic Toxicology,School of Public Health,Jilin University,Changchun 130021;Inhibitive effects of gallic acid on proliferation of murine gastric cancer and hepatoma-22 cells[J];Journal of Zhengzhou University(Medical Sciences);2012-03
4 WEN Chun-miao1,YANG Run-ping1,MEI Ning-ju2,DONG Ya3,LI Heng-jin1,ZHAO Hua1 1Department of Dermatology,Chinese PLA General Hospital,Beijing 100853,China;2Department of Dermatology,Xining No.1 People's Hospital,Xining 810000,Qinghai Province,China;3Department of Dermatology,Zhuozhou Hospital,Zhuozhou 072750,Hebei Province,China;Inhibitory effect of mustard seeds on type 1 hypersensitivity[J];Journal of Chinese PLA Postgraduate Medical School;2012-06
5 ZHANG KE-SHUANG,KONG XIN-JUAN,ZHAO QING-XI,et al(Department of Gastroenterology,The Affiliated Hospital Qingdao University Medical College,Qingdao 266003,China);THE EXPRESSION OF c-met AND ITS ASSOCIATION WITH TUMOR ANGIOGENESIS IN COLORECTAL CANCER[J];Medical Journal of Qilu;2010-04
6 ZHAI Yun-peng,XU Wei,CHANG Hong,LI Gang,LIU Fang-feng,QIN Cheng-kun,ZHANG Zhen-hai Department of General Surgery,Provincial Hospital Affiliated to Shandong University(Jinan 250021,China);Influence of siRNA silencing expression of Livin gene on the biological behavior of HepG2 cells[J];Chinese Journal of Current Advances in General Surgery;2012-12
7 Lei Hou,Department of Gastroenterology,the Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei Province,China Ming-Ming Zhao,Department of Operation,the Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei Province,China Bao-Ming Sun,Department of General Surgery,Tangsanying Hospital of Longhua County,Chengde 068150,Hebei Province,China Yan-Tao Tian,Cancel Institute and Hospital,Chinese Academy of Medical Sciences,Beijing 100021,China;Correlation between c-Met expression and tumor angiogenesis in colorectal cancer[J];World Chinese Journal of Digestology;2013-08
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Kai-lei,LI Le-ping,JING Chang-qing Department of Gastrointestinal Surgery,Provincial Hospital Affiliated to Shandong University(Jinan 250021,China);Reversal of multidrug resistance in human colon carcinoma LOVO/5-Fu cells by short hairpin RNA expression plasmids[J];Chinese Journal of Current Advances in General Surgery;2010-11
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