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《Chinese Journal of Cancer Prevention and Treatment》 2012-01
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Prevention effect of mustard seed on colorectal cancer in rats induced by DMH in vivo

ZHU Ming-gu1,GUO Wen1,YUAN Hai-feng2,LI Xin-yan1,CHEN Chu-di1 1.Department of Gastroenterology,Guangdong Provincial Key Laboratory of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,P.R.China 2.Department of Gastroenterology,Heze Municipal Hospital,Heze 274614,P.R.China  
OBJECTIVE: To observe the effect of mustard seed(MS) against colorectal cancer in rats induced by 1,2-dimethylhydrazine(DMH) in vivo.METHODS: The colorectal cancer model induced by DMH intraperitoneal injection.The effect of mustard seed on the incidence of colorectal cancer,spleen index and thymus index were observed.RESULTS:The colorectal cancer model was successfully established in this experiment.The incidence of colorectal adenocarcinoma in DMH group was 83.33%(10/12),the adenoma incidence was 16.67%(2/12),the total tumor incidence was 100%(12/12),and the liver and mesenteric lymph node metastasis rate was 58.33%(7/12).The incidence of adenocarcinoma in 5% MS group and 7.5%MS group was 58.33% and 75.00% respectively lower than that in DMH group(χ2=15.662,P=0.000).The liver and mesenteric lymph node metastasis rate of colorectal cancer in 5% MS group and 7.5%MS group was 41.66% and 50.00% respectively lower than that in DMH group(χ2=8.585,P=0.014).And the incidence of total colorectal tumor in 5% MS group and 7.5%MS group was 66.67%(8/12) and 41.70%(5/12) respectively lower than that in DMH group(χ2=9.687,P=0.008).While the incidence of colorectal adenoma in 5% MS group(41.67%,5/12) and 7.5%MS group(33.33%,4/12) was slightly higher than that in DMH group(16.67%,2/12).The thymus and spleen index of rats in 7.5%MS group were markedly higher than that in DMH group(P=0.013;P=0.037).And the thymus index of rats in 5%MS group was also markedly higher than that of DMH group(P=0.039).CONCLUSION: MS have the effects of preventing colorectal cancer induced by DMH,and it can improve organism's immunefunction.
【Fund】: 广东省自然科学基金(9151040701000025);; 广东省科技计划项目(2010B060900054);; 南方医院院长基金(2009B011)
【CateGory Index】: R735.34
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